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Oligonuleotide Delivery with Dendritic Poly(L-lysine) for Treatments of the Liver Disorders

Published online by Cambridge University Press:  31 January 2011

Kazuto Watanabe ,
Mriko Harada-Shiba ,
Akira Suzuki ,
Yuriko Higuchi ,
Shigeru Kawakami ,
Mitsuru Hashida ,
Risa Gokuden ,
Ryohsuke Kurihara ,
Yusuke Sugao  and
Takeshi Mori
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Kazuto Watanabe
Affiliation:
[email protected], Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Mriko Harada-Shiba
Affiliation:
[email protected], National Cardiovascular Center Research Institute, Department of Bioscience, Osaka, Japan
Akira Suzuki
Affiliation:
[email protected], National Cardiovascular Center Research Institute, Department of Bioscience, Osaka, Japan
Yuriko Higuchi
Affiliation:
[email protected], Kyoto University, Department of Drug Delivery Research, Kyoto, Japan
Shigeru Kawakami
Affiliation:
[email protected], Kyoto University, Department of Drug Delivery Research, Kyoto, Japan
Mitsuru Hashida
Affiliation:
[email protected], Kyoto University, Department of Drug Delivery Research, Kyoto, Japan
Risa Gokuden
Affiliation:
[email protected], Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Ryohsuke Kurihara
Affiliation:
[email protected], Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Yusuke Sugao
Affiliation:
[email protected], Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Takeshi Mori
Affiliation:
[email protected], Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Yoshiki Katayama
Affiliation:
[email protected], Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Takuro Niidome
Affiliation:
[email protected]@mbox.nc.kyushu-u.ac.jp, Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
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Abstract

A cationic peptide dendrier, dendritic poly(L-lysine), forms complexes with oligonucleotides and can deliver them to liver after intravenous injection. Here, we tried to deliver apolipoprotein B-specific siRNA for the treatment of hypercholesterolemia and NFκB decoy for the hepatitis treatment. Significant therapeutic effects in those disease model mice were observed after intravenous injection of the oligonucleotides complexes with dendritic poly(L-lysine).

Keywords

biomaterialnanoscalepolymer
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1237: Symposium TT – Nanobiotechnology and Nanobiophotonics - Opportunities and Challenges , 2009 , 1237-TT05-12
Copyright
Copyright © Materials Research Society 2010

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