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Nanotubes and nanoparticles based 3D scaffolds for the construction of high performance Biosensors

Published online by Cambridge University Press:  04 June 2014

Meenakshi Singh ,
Michael Holzinger ,
Maryam Tabrizian  and
Serge Cosnier
Meenakshi Singh
Affiliation:
Université Joseph Fourier, Département de Chimie Moléculaire UMR-5250, ICMG FR-2607, CNRS, Grenoble, France.
Michael Holzinger
Affiliation:
Université Joseph Fourier, Département de Chimie Moléculaire UMR-5250, ICMG FR-2607, CNRS, Grenoble, France.
Maryam Tabrizian
Affiliation:
McGill University, Biomat'X Research Laboratories, Dept. of Biomedical Engineering and Faculty of Dentistry, Montréal, Canada.
Serge Cosnier
Affiliation:
Université Joseph Fourier, Département de Chimie Moléculaire UMR-5250, ICMG FR-2607, CNRS, Grenoble, France.
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Abstract

3D scaffolds with different pore sizes, using single-walled carbon nanotubes (SWCNTs) and nanoparticles of different size were constructed. Biotinylated glucose oxidase (GOX-B) and anti-cholera toxin (anti-CT) were immobilized onto the one and two level nanoscaffolds, functionalized with pyrene-β-cyclodextrin for the construction of glucose based enzyme sensors and immunosensors, respectively. For enzyme sensors, highest current density and sensitivity (41.72 μA cm-2, 3 mA M-1 cm-2) were obtained with two level scaffolds made with 100 nm nanoparticles. In contrast to this, for immunosensors, highest current density and sensitivity (11.71 μA cm-2, 116.2 μA M-1 cm-2) were obtained with two level scaffolds made with 500 nm nanoparticles, indicating that the pore sizes can be adjusted using different size of nanoparticles for the respective applications.

Keywords

nanostructuresurface chemistryscanning electron microscopy (SEM)
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1700: Symposium MM – Nanotubes and Related Nanostructures--2014 , 2014 , pp. 97 - 102
Copyright
Copyright © Materials Research Society 2014 

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References

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