Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-05T09:00:43.448Z Has data issue: false hasContentIssue false
  • English
  • Français

Nanoporous Gold: A Biomaterial for Microfabricated Drug-Delivery Platforms

Published online by Cambridge University Press:  12 January 2012

Erkin Seker ,
Yevgeny Berdichevsky ,
Kevin J. Staley  and
Martin L. Yarmush
Erkin Seker
Affiliation:
Department of Electrical and Computer Engineering, University of California, Davis, CA, USA Center for Engineering in Medicine, Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA Shriners Hospitals for Children, Boston, MA, USA
Yevgeny Berdichevsky
Affiliation:
Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
Kevin J. Staley
Affiliation:
Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
Martin L. Yarmush
Affiliation:
Center for Engineering in Medicine, Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA Shriners Hospitals for Children, Boston, MA, USA Department of Biomedical Engineering, Rutgers University, Piscataway, NJ, USA
Get access

Abstract

Nanoporous gold (np-Au) is a promising nanostructured material with many desirable properties, including large surface area-to-volume ratio, corrosion resistance, high conductivity, and well-studied thiol-based surface chemistry. While np-Au has been used in a variety of applications, from fuel cells to electrochemical sensors, its interface with biology, where many of its exciting applications lie, is surprisingly non-existent. This paper reports on drug delivery from np-Au thin films for modifying cell proliferation in situ. We expect that establishing np-Au as a biomaterial with drug delivery capabilities will create new opportunities for engineering advanced BioMEMS devices that can monitor and modulate biological processes in both in vitro and in vivo settings.

Keywords

biomaterialnanostructureAu
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1415: Symposium HH/II/TT – MEMS, BioMEMS and Bioelectronics–Materials and Devices , 2012 , mrsf11-1415-ii07-04
Copyright
Copyright © Materials Research Society 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Roco, M. C., Curr. Opin. Biotechnol. 14 (3), 337 (2003).Google Scholar
2. Erlebacher, J., Aziz, M., Karma, A., Dimitrov, N. and Sieradzki, K., Nature 410 (6827), 450 (2001).Google Scholar
3. Seker, E., Reed, M. and Begley, M., Materials 2 (4), 2188 (2009).Google Scholar
4. Ding, Y. and Chen, M., Materials Research Society Bulletin 24 (8), 569 (2009).Google Scholar
5. Weissmüller, J., Newman, R., Jin, H., Hodge, A. and Kysar, J., Materials Research Society Bulletin 34 (8), 577 (2009).Google Scholar
6. Seker, E., Berdichevsky, Y., Begley, M., Reed, M., Staley, K. and Yarmush, M., Nanotechnology 21, 125504 (2010).Google Scholar
7. Morikawa, M., Fryer, J. D., Sullivan, P. M., Christopher, E. A., Wahrle, S. E., DeMattos, R. B., O’Dell, M. A., Fagan, A. M., Lashuel, H. A. and Walz, T., Neurobiology of Disease 19 (1–2), 66 (2005).Google Scholar
8. Dyhrfjeld-Johnsen, J., Berdichevsky, Y., Swiercz, W., Sabolek, H. and Staley, K., Journal of Clinical Neurophysiology 27 (6), 418 (2010).Google Scholar
9. Seker, E., Begley, M., Reed, M. and Utz, M., Appl. Phys. Lett. 92, 013128 (2008).Google Scholar
10. Parida, S., Kramer, D., Volkert, C., Rösner, H., Erlebacher, J. and Weissmüller, J., Phys. Rev. Lett. 97 (3), 35504 (2006).Google Scholar
11. Seker, E., Gaskins, J., Bart-Smith, H., Zhu, J., Reed, M., Zangari, G., Kelly, R. and Begley, M., Acta Mater. 55 (14), 4593 (2007).Google Scholar
12. Stevens, M. M. and George, J. H., Science 310 (5751), 1135 (2005).Google Scholar