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A combinatorial approach to enhance the biocompatibility and heatingefficiency of magnetic hyperthermia- Serum Albumin conjugatedferrimagneticmagnetite nanoparticles

Published online by Cambridge University Press:  18 January 2016

Viveka Kalidasan ,
Xiaoli Liu ,
Jun Ding ,
Ananya Dasgupta  and
Sreedharan Sajikumar
Viveka Kalidasan
Affiliation:
Department of Materials Science and Engineering, EA-03-09, 9 Engineering Drive, National University of Singapore, Singapore-117575
Xiaoli Liu
Affiliation:
Department of Materials Science and Engineering, EA-03-09, 9 Engineering Drive, National University of Singapore, Singapore-117575
Jun Ding*
Affiliation:
Department of Materials Science and Engineering, EA-03-09, 9 Engineering Drive, National University of Singapore, Singapore-117575
Ananya Dasgupta
Affiliation:
Department of Physiology, NUS Yong Loo Lin School of Medicine, Block MD9, 2 Medical Drive #04-01, Singapore 117597
Sreedharan Sajikumar
Affiliation:
Department of Physiology, NUS Yong Loo Lin School of Medicine, Block MD9, 2 Medical Drive #04-01, Singapore 117597
*
*Corresponding Author ([email protected])
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Abstract

Magnetic hyperthermia is a non-invasive cancer treatment method which is usedsynergistically with the current cancer treatments. Improved biocompatibilityand enhanced heating characteristics are the pressing challenges to be addressedin magnetic hyperthermia. Through a novel combinatorial approach, we haveattempted to address both the challenges. Ferrimagneticmagnetite nanoparticles(FMNPs)of size 50 nm were synthesized by thermal decomposition method and wereconverted to hydrophilic phase by 3-Aminopropyltrimethoxysilane (APTMS). SerumAlbumin (SA) from rat was conjugated over the APTMS-FMNPs to convert tobiocompatible phase. The preliminary haemolysis experiments show that SA-FMNPsare non-haemolytic (1.2 % haemolysis). It is observed from the magnetic heatingexperiments that due to better colloidal stability, the Specific Absorption Ratevalue of the SA-FMNPs are higher (2100 W/g) than the FMNPs without SA (1400W/g). Thus we report here that SA conjugation over FMNPs (with a high saturationmagnetization of 75 emu/g) provides a novel combinatorial approach to enhanceboth the biocompatibility and the SAR value for magnetic hyperthermia.

Keywords

magnetic propertiesbiomedicalchemical synthesis
Type
Articles
Information
MRS Advances , Volume 1 , Issue 3: Nanomaterials and Synthesis , 2016 , pp. 247 - 254
Copyright
Copyright © Materials Research Society 2016 

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