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Very Cool Clathrin

Published online by Cambridge University Press:  14 March 2018

Stephen W. Carmichael
Stephen W. Carmichael*
Affiliation:
Mayo Clinic
*
[email protected]

Extract

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Clathrin-coated vesicles are the shuttle containers within cells. The vesicles carry lipids and proteins between membrane-bound compartments. Clathrin forms a cage-like structure around the membrane-bound vesicle that is pinched off from the plasma membrane (in endocytosis) or a membranous component of the cytoplasm. Clathrin recruits cargo that is within a vesicle through intermediary proteins known as adaptors that help select membrane-anchored protein and form an interface between the clathrin cage and the membrane bilayer.

Type
Research Article
Information
Microscopy Today , Volume 13 , Issue 6 , November 2005 , pp. 3 - 7
Copyright
Copyright © Microscopy Society of America 2005

Footnotes

1

The author gratefully acknowledges Dr. Stephen Harrison for reviewing this article.

References

2 Fotin, A., Cheng, Y., Sliz, P., Grigorieff, N., Harrison, S.C., Kirchhausen, T., and Walz, T., Molecular model for a complete clathrin lattice from electron cryomicroscopy, Nature 432:573-579,2004.Google Scholar
3 Fotin, A., Cheng, Y., Grigorieff, N., Walz, T., Harrison, S.C., and Kirchhausen, T., Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating, Nature 432:649-53, 2004.Google Scholar