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Published online by Cambridge University Press: 14 March 2018
The atomic force microscope (AFM), the workhorse of scanning probe microscopes, has become even more versatile. Anneliese Raab, Wenhai Han, Dirk Badt, Sandra Smith-Gill, Stuart Lindsay, Hansgeorg Schindler, and Peter Hinterdorfer have demonstrated that the AFM, in the dynamic force mode, can use antibodies as a probe. Dynamic force microscopy uses a magnetized tip that is oscillated in an alternating magnetic field as the tip scans the surface. This provides a very gentile interaction that can be recorded as a high resolution topographic image. Raab et al., showed that more information can be obtained from the specimen.
2. Raab, A., Han, W., Badt, D., Smith-Gill, S.J., Lindsay, S.W., Schindler, H., and Hinterdorfer, P., Antibody recognition imaging by force microscopy, Nature Biotechnology 17:902-905.Google Scholar