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Tracking Cells in Embryos

Published online by Cambridge University Press:  14 March 2018

Stephen W. Carmichael*
Affiliation:
Mayo Clinic

Extract

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Ever since the first embryo was put under a microscope, scientists have been trying to determine which embryonic cells form which structures in the mature organism. Classic methods were to kill (ablate) certain cells and see what structures were malformed or missing when the animal developed. More recently, cells have been labeled with visible tags and the tagged cells traced through development. One problem is that the tag gets diluted by half each time a labeled cell divides. A new labeling method that shows a lot of promise has been demonstrated by David Piston, Robert Summers, Susan Knobel, and John Morrill.

Type
Research Article
Copyright
Copyright © Microscopy Society of America 1999

References

2. Piston, D.W., Summers, R.G., Knobel, S.M., and Morreli, J.B., Characterization of involution during sea urchin gastrulation using two-photon excited photorelease and confocal microscopy, Microsc. Microanal. 4-404-414, 1998.Google Scholar