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Plugging A Small Hole

Published online by Cambridge University Press:  14 March 2018

Stephen W. Carmichael*
Affiliation:
Mayo Clinic

Extract

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It has long been appreciated that communication between the nucleus and the cytoplasm of a cell occurs through the nuclear pores. Regulation of this communication has remained a mystery. A breakthrough in our understanding of this regulation was recently presented by Carmen Perez- Terzic, Jason Pyle, Marisa Jaconi, Lisa Stehnc-Bittel, and David Clapham of Mayo Clinic. Using field emission scanning electron microscopy (FESEM), transmission electron microscopy, and atomic force microscopy (AFM), they demonstrated the presence of a small plug within the nuclear pore that was present under certain physiologic circumstances. This “plug“ may regulate the movement of molecules through the pore.

Type
Research Article
Copyright
Copyright © Microscopy Society of America 1997

References

Note

1 Perez-Terzic, C,Pyie, J., Stehno-Bittel, L.,Clapham, D.E, Conformationaf states of the nuclear pore complex induced by depletion of nuclear CA2+ stores Science 273:1875-1877, 1996.Google ScholarPubMed