Ever since membranes could be resolved within cells, the pattern of intracellular membrane trafficking has been under investigation. Images made with the transmission electron microscope revealed numerous small vesicles that appeared to be shuttling between the endoplasmic rettculum (ER) and the Golgi complex. However, these static images offered no information as to the direction trie vesicles were moving and were quite inconclusive. Nevertheless, evidence built over time to suggest that unrefined proteins were moved in small vesicles from one intracellular compartment to another. Recently, a study by John Presley, Nelson Cole, Trina Schroer, Koret Hirschberg, Kristen Zaal, and Jennifer Lippincott- Schwartz with the light microscope has challenged this view. They not only presented convincing morphologic data in their published article, but they also posted some Quicktime movies on a Web site (http://dir.nichd.nih.gov/CBMB/pb1labob.html) that are even more convincing.