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Microscopes aren't just for Microscopists, Anymore!

Published online by Cambridge University Press:  14 March 2018

Stephen W. Carmichael*
Affiliation:
Mayo Clinic

Extract

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Historically, microscopes have been used to gather morphologic data. We have called people who use these instruments microscopists, and it is implied that microscopists are morphologists. As was pointed out in the April/May issue of this newsletter, useful information about a specimen is also gained from temporal analysis. Further, it has been appreciated that the new family of scanning probe microscopes can be used to gather additional types of information so that these instruments have the potential to be useful beyond the dreams of a conventional microscopist. As we will discuss in this article, the future is here for one such application.

The atomic force microscope (AFM) takes advantage of the leverage afforded by the deflection of a laser beam bounced off a cantilevered stylus that is scanned over the surface of a specimen.

Type
Research Article
Copyright
Copyright © Microscopy Society of America 1994

References

2. Florin, E.-L, Moy, V.T., and Gaub, H.E.. Adhesion forces between individual ligand-receptor pairs. Science 264:415417, 1994 CrossRefGoogle ScholarPubMed.

3. Ghislain, L.P., and Webb, W.W., Scanning-force microscope based on an opiicaf trap, Optics Letters 18:16781680, 1993 CrossRefGoogle ScholarPubMed