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Intermediate Magnification Imaging System for Whole Organs/Organisms

Published online by Cambridge University Press:  14 March 2018

Richard W. Cole ,
Carmen A. Mannella ,
Christian Renken  and
James N. Turner
Richard W. Cole
Affiliation:
Division of Genetic Disorders, Wadsworth Center, Albany, NY
Carmen A. Mannella
Affiliation:
Resource for Visualization of Biological Complexity, Wadsworth Center, Albany, NY
Christian Renken
Affiliation:
Resource for Visualization of Biological Complexity, Wadsworth Center, Albany, NY
James N. Turner
Affiliation:
Division of Genetic Disorders, Wadsworth Center, Albany, NY

Extract

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There are many techniques for 3D imaging of biological specimens such as confocal, two-photon and, wide-field fluorescence microscopy, CAT scan, MRI, and optical coherence tomography. There are also many derivatives of these techniques, each having its strengths and weaknesses. Due to the differences in resolution, depth-of-field, and field-of-view, it is often difficult to compare images from the relatively high-resolution microscopy methods to the latter lower-resolution high-volume imaging methods. Effectively making this comparison could be very powerful in relating organ or organism level information to cellular level processes.

Type
Research Article
Information
Microscopy Today , Volume 14 , Issue 6 , November 2006 , pp. 48 - 51
Copyright
Copyright © Microscopy Society of America 2006

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