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Imaging Motile Pathogens with Light Microscopy and Cryogenic Electron Tomography

Published online by Cambridge University Press:  01 December 2009

Freddy Frischknecht*
Affiliation:
Department of Parasitology, Hygiene Institute, University of Heidelberg Medical School, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
Marek Cyrklaff
Affiliation:
Department of Parasitology, Hygiene Institute, University of Heidelberg Medical School, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany

Extract

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The most prominent vector-transmitted diseases in the first and third world are Lyme disease and malaria, respectively. In both cases the transmitted agents are introduced into the skin from where they eventually disseminate into the blood using active motility. We are interested in deciphering the molecular mechanisms underlying the motility of these pathogens and how they relate to the ultrastructure of the pathogens. Here we provide an overview of the microscopy techniques that we use to achieve these goals.

Type
Biological Applications
Copyright
Copyright © Microscopy Society of America 2009