Resolution and pixel number is a recurring question in microscopy, especially in regards to appreciating or visualizing the image's resolution once an image is captured. For instance, what is the effect of changing a one megapixel camera for a three megapixel camera? It is important to consider nanometers (or micrometers) per pixel, which will determine the ultimate resolution available. Of course Nyquist will tell you that you can't push things to the single-pixel dimensions—a couple of pixels is more likely the limit.

It is also important to remember that raw pixel count alone is meaningless. The image formation process must be considered. The camera needs to be matched to the phosphor for optimum cost and performance.