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Active Optics Improve Microscope’s Field of View

Published online by Cambridge University Press:  14 March 2018

Benjamin Potsaid  and
John T. Wen
Benjamin Potsaid*
Affiliation:
Center for Automation Technologies and Systems Rensselaer Polytechnic Institute, Troy, New York
John T. Wen*
Affiliation:
Center for Automation Technologies and Systems Rensselaer Polytechnic Institute, Troy, New York
*
[email protected]
[email protected]

Extract

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Since the earliest explorations of the microscopic world in the 17th century and continuing to the present day, microscopists have continuously faced a challenge in that there is an inherent tradeoff between the resolution of the microscope and the size of the field of view--as the resolution of the microscope is increased to resolve smaller features, the observable area of the specimen decreases proportionally. While being a long recognized characteristic of the traditional microscope design, this tradeoff is becoming a significant hindrance as optical microscopes are being used in automated systems for advanced biotech research, medical diagnostics, robotic micromanipulation, and industrial inspection.

Type
Research Article
Information
Microscopy Today , Volume 14 , Issue 4 , July 2006 , pp. 16 - 23
Copyright
Copyright © Microscopy Society of America 2006

References

[1] Smith, W. J., Modern Lens Design, Second Edition, SPIE, Ed. McGraw-Hill, 2005.Google Scholar
[2] Bifano, T., Perreault, J., Bierden, P., and Dimas, C., “Micromachined deformable mirrors for adaptive optics,” in High-resolution wavefront control: methods, devices, and applications IV, Proc. SPIE 4825, pp. 10–13, 2002.Google Scholar
[3] Potsaid, B., Bellouard, Y., and Wen, J. T., “Adaptive scanning optical microscope (ASOM): A multidisciplinary optical microscope design for large field of view and high resolution imaging,” Opt. Express, no. 17, pp. 6504–6518, 2005. [Online]. Available: http://www.opticsexpress.org/abstract.cfm?URI=OPEX-13-17-6504 Google Scholar