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Unlocking secrets of inhalation blends through X-ray Computed Tomography and Microscopy

Published online by Cambridge University Press:  30 July 2021

Hrishikesh Bale
Affiliation:
Carl Zeiss Microscopy Inc., Dublin, California, United States
Robert Hammond
Affiliation:
University of Leeds, Leeds, England, United Kingdom
Parmesh Gajjar
Affiliation:
School of Materials, The University of Manchester, Oxford Road, Manchester, England, United States
Ioanna Danai Styliari
Affiliation:
University of Hertfordshire, Hatfield, United Kingdom
Philip Withers
Affiliation:
University of Manchester, Manchester, England, United Kingdom
Darragh Murnane
Affiliation:
University of Hertfordshire, Hatfield, United Kingdom

Abstract

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Type
Imaging, Microscopy, and Micro/Nano-Analysis of Pharmaceutical, Biopharmaceutical, and Medical Health Products
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Microscopy Society of America

References

Fu, X, Elliott, JA, Bentham, AC, Hancock, BC, Cameron RE: Application of X-ray Microtomography and Image Processing to the Investigation of a Compacted Granular System. Part Part Syst Charact WILEY-VCH Verlag; 2006, 23: 229–36.CrossRefGoogle Scholar
Shur, J, Price R: Advanced microscopy techniques to assess solid-state properties of inhalation medicines. Adv Drug Deliv Rev 2012, 64: 369–82.CrossRefGoogle ScholarPubMed
Gajjar, P, Styliari, ID, Burnett, TL, Chen, X, Elliott, JA, Ganley, WJ, et al. : Multiscale Tomography: Probing the Nano-, Micro-, and Meso-scale Resolution of Inhalation Powder Structure. In: Bryon, PR, Hindle, M, Peart, J, Traini, D, Young, PM, Farr, SJ, et al. , editors. Respir Drug Deliv Eur 2019 River Grove, IL; 2019. p. 155–68.Google Scholar
Kinnunen, H, Hebbink, G, Peters, H, Shur, J, Price R: An Investigation into the Effect of Fine Lactose Particles on the Fluidization Behaviour and Aerosolization Performance of Carrier-Based Dry Powder Inhaler Formulations. AAPS PharmSciTech. Boston; 2014. p. 898909.Google Scholar
Finlay, WH: The Mechanics of Inhaled Pharmaceutical Aerosols :, An Introduction. Elsevier Science; 2001.Google Scholar