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Structural dynamics of human FACT protein complex: electron microscopy analysis

Published online by Cambridge University Press:  30 July 2021

Olesya Volokh ,
Anastasiia Sivkina ,
Maria Karlova ,
Elena Kotova ,
Vasily Studitsky  and
Olga Sokolova
Olesya Volokh
Affiliation:
Moscow Lomonosov University, United States
Anastasiia Sivkina
Affiliation:
Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia., United States
Maria Karlova
Affiliation:
Moscow Lomonosov University, United States
Elena Kotova
Affiliation:
Fox Chase Cancer Center, United States
Vasily Studitsky
Affiliation:
Fox Chase Cancer Center, Philadelphia, PA 19111, USA., Philadelphia, Pennsylvania, United States
Olga Sokolova
Affiliation:
Moscow Lomonosov University, United States

Abstract

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Type
3D Structures: From Macromolecular Assemblies to Whole Cells (3DEM FIG)
Information
Microscopy and Microanalysis , Volume 27 , Supplement S1 , August 2021 , pp. 1700 - 1702
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Microscopy Society of America

References

Gurova, K., et al. , Structure and function of the histone chaperone FACT – Resolving FACTual issues. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2018. 1861(9): p. 892-904.CrossRefGoogle Scholar
Valieva, M.E., et al. , Stabilization of Nucleosomes by Histone Tails and by FACT Revealed by spFRET Microscopy.Cancers (Basel), 2017. 9(1).CrossRefGoogle ScholarPubMed
Chang, H.W., et al. , Mechanism of FACT removal from transcribed genes by anticancer drugs curaxins. Sci Adv, 2018. 4(11): p. eaav2131.Google ScholarPubMed
McCullough, L.L., et al. , Functional roles of the DNA-binding HMGB domain in the histone chaperone FACT in nucleosome reorganization. J Biol Chem, 2018. 293(16): p. 6121-6133.CrossRefGoogle Scholar
Mayanagi, K., et al. , Structural visualization of key steps in nucleosome reorganization by human FACT. Sci Rep, 2019. 9(1): p. 10183.CrossRefGoogle ScholarPubMed
Liu, Y., et al. , FACT caught in the act of manipulating the nucleosome. Nature, 2020. 577(7790): p. 426-431.CrossRefGoogle ScholarPubMed
This work was supported by the Russian Science Foundation (#19-74-30003). Electron microscopy was performed on the Unique equipment setup “3D-EMС” of Moscow State University, Department of Biology.Google Scholar