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Optimizing Throughput for Cryo-EM Data Collection in Drug Discovery

Published online by Cambridge University Press:  30 July 2021

Stephen Mick
Affiliation:
Gatan, United States
Sahil Gulati
Affiliation:
Gatan, United States
Christopher Booth
Affiliation:
Gatan, United States

Abstract

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Type
Imaging, Microscopy, and Micro/Nano-Analysis of Pharmaceutical, Biopharmaceutical, and Medical Health Products
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Microscopy Society of America

References

Kühlbrandt, W., (2014), The Resolution Revolution, Science, 343 (6178), 1443-1444, doi:10.1126/science.1251652.CrossRefGoogle ScholarPubMed
Hanske, J., Sadian, Y., Müller, C.W., (2018), The cryo-EM resolution revolution and transcription complexes, Current Opinions in Structural Biology, 52:8-15, doi.org/10.1016/j.sbi.2018.07.002.CrossRefGoogle ScholarPubMed
de Oliveira, Maia, van Beek, T., Shilliday, L., Debreczeni, F., Phillips, J.E., C., (2020), Cryo-EM: The Resolution Revolution and Drug Discovery, SLAS Discovery: Advancing the Science of Drug Discovery, 26(10), 17-31, doi.org/10.1177/2472555220960401.CrossRefGoogle ScholarPubMed
Weis, F., Hagen, W., (2020), Combining high throughput and high quality for cryo-electron microscopy data collection, Acta Crystallographica Section D: Structural Biology, 76(8), 724-728, doi.org/10.1107/S2059798320008347.CrossRefGoogle ScholarPubMed