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Morphometry of Synapse and Granule Cell Changes in the Hippocampus of Aging Fischer 344 Rats

Published online by Cambridge University Press:  02 July 2020

S. L. White ,
C. L. Gatlin ,
J. W. Horn ,
H. E. Shannon ,
W. C. Smith  and
W. H. Jordan
S. L. White
Affiliation:
Toxicology Research Laboratories, Lilly Research Laboratories, Greenfield, IN46140
C. L. Gatlin
Affiliation:
Toxicology Research Laboratories, Lilly Research Laboratories, Greenfield, IN46140
J. W. Horn
Affiliation:
Toxicology Research Laboratories, Lilly Research Laboratories, Greenfield, IN46140
H. E. Shannon
Affiliation:
Toxicology Research Laboratories, Lilly Research Laboratories, Greenfield, IN46140
W. C. Smith
Affiliation:
Toxicology Research Laboratories, Lilly Research Laboratories, Greenfield, IN46140
W. H. Jordan
Affiliation:
Toxicology Research Laboratories, Lilly Research Laboratories, Greenfield, IN46140
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Extract

Morphologic changes in Alzheimer’s disease (AD) include a decrease in synapse number while the surviving synapses are increased in size by a process known as compensatory synaptogenesis. There is disagreement among investigators as to whether the synapse changes observed in AD in humans also occurs in the aging rat. The hippocampus, plays a significant role in learning and memory in both humans and rats and is known to be particularly susceptible to cell loss associated with aging. s In the rat hippocampus, age-related synaptic density declines as much as 27% have been reported by some authors, while other investigators have failed to detect a change in synapse number with age. A secondary factor in the total number of synapses in the dentate gyrus is the number of granule cells. Proliferation or regeneration (neurogenesis) of hippocampal granule cells is known to occur well into the adult life of the rat. The goal of the current study was to further explore age-related changes in rat hippocampal synapses and granule cells using the disector morphometry method.

Type
Imaging Cells and Organelles
Information
Microscopy and Microanalysis , Volume 3 , Issue S2: Proceedings: Microscopy & Microanalysis '97, Microscopy Society of America 55th Annual Meeting, Microbeam Analysis Society 31st Annual Meeting, Histochemical Society 48th Annual Meeting, Cleveland, Ohio, August 10-14, 1997 , August 1997 , pp. 267 - 268
Copyright
Copyright © Microscopy Society of America 1997

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