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Matrix Protein Structural Analysis of Brain Aneurysms by Polarizing Microscopy

Published online by Cambridge University Press:  02 July 2020

Peter B. Canham ,
Helen M. Finlay  and
Jay D. Humphrey
Peter B. Canham
Affiliation:
Department of Medical Biophysics, University of Western Ontario London, Ontario, N6A 5C1
Helen M. Finlay
Affiliation:
Department of Medical Biophysics, University of Western Ontario London, Ontario, N6A 5C1
Jay D. Humphrey
Affiliation:
Biomedical Engineering Program, Texas A & M University, College Station, TX, 77843-3120.
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Extract

The wall of saccular brain aneurysms, lesions that develop at the fork regions of human brain arteries, is a layered multidirectional fabric of fibrous collagen. The wall tissue has the mechanical features of high elastic stiffness and a low tensile strength compared to adjacent arteries. Arterial blood pressure within the sac of an aneurysm stresses the wall in all tangential directions; thus an area of mechanical weakness may be characterized by an area lacking fibre strength, or an area with inadequately aligned fibres.

The collagen fibres of the wall are birefringent, with many fibre types, similar to wound healing skin (types I, III, IV, V, VI) The known correlation between fibre birefringence and tissue strength for dermal wound healing3 provided the opportunity in this research to calculate strength maps to compare one lesion from another, and to make regional comparisons around a single lesion.

Type
Imaging of Vascular Disorders
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 544 - 545
Copyright
Copyright © Microscopy Society of America

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References

References:

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