Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-20T02:04:43.487Z Has data issue: false hasContentIssue false
  • English
  • Français

Liver Toxicity in Rats Fed A Mixture of Pcb Congeners and 2,3,7,8-Tcdd

Published online by Cambridge University Press:  02 July 2020

B.J. Cornell ,
A. Singh  and
I. Chu
B.J. Cornell
Affiliation:
Atlantic Veterinary College, Charlottetown, PECanadaCIA 4P3
A. Singh
Affiliation:
Atlantic Veterinary College, Charlottetown, PECanadaCIA 4P3
I. Chu
Affiliation:
Environmental Health Directorate, Health Protection Branch, Tunney's Pasture, Ottawa, ON, CanadaK1A 0L2
Get access

Extract

Polyhalogenated aromatic compounds such as polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins (PCDDs) continue to be environmental contaminants because of their bioaccumulation in the food chain and high resistance to biodegradation. The current study was undertaken to determine if a mixture of PCB congeners (WHO-IPCS) were interactive with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in producing morphological changes in the rat liver. Both compounds are known to produce a broad range of biochemical and morphological alterations including enzyme induction.

Groups (N=5) of female Sprague-Dawley rats were administered TCDD (0, 2.5, 25, 250, 1000 ng/kg bw/day) or PCB (0, 2, 20 μg/kg bw/day) alone, or in combination with each concentration of both compounds. Incorrect concentrations were published in a previous abstract. The test substance was mixed with corn oil and given by gavage at 2 ml/kg daily for 28 days. At the end of the experiment, the rats were killed and liver samples were prepared for transmission electron microscopy.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 3 , Issue S2: Proceedings: Microscopy & Microanalysis '97, Microscopy Society of America 55th Annual Meeting, Microbeam Analysis Society 31st Annual Meeting, Histochemical Society 48th Annual Meeting, Cleveland, Ohio, August 10-14, 1997 , August 1997 , pp. 51 - 52
Copyright
Copyright © Microscopy Society of America 1997

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Kimbrough, R.D., Crit. Rev. Toxicol. 133(1995)133.10.3109/10408449509021611CrossRefGoogle Scholar
2Ahlborg, U.G.et al., Chemosphere 28(1994)1049.10.1016/0045-6535(94)90324-7CrossRefGoogle Scholar
3H. Safe, , Crit. Rev. Toxicol. 24(1994)87.10.3109/10408449409049308CrossRefGoogle Scholar
4Connell, B.J.et al. USGEB Abst. March, 1997.Google Scholar
5Singh, A.et al., Ultrastruct. Pathol. 20(1996)275.10.3109/01913129609016325CrossRefGoogle Scholar