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Liver Toxicity in Rats Fed A Mixture of Pcb Congeners and 2,3,7,8-Tcdd

Published online by Cambridge University Press:  02 July 2020

B.J. Cornell
Affiliation:
Atlantic Veterinary College, Charlottetown, PECanadaCIA 4P3
A. Singh
Affiliation:
Atlantic Veterinary College, Charlottetown, PECanadaCIA 4P3
I. Chu
Affiliation:
Environmental Health Directorate, Health Protection Branch, Tunney's Pasture, Ottawa, ON, CanadaK1A 0L2
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Extract

Polyhalogenated aromatic compounds such as polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins (PCDDs) continue to be environmental contaminants because of their bioaccumulation in the food chain and high resistance to biodegradation. The current study was undertaken to determine if a mixture of PCB congeners (WHO-IPCS) were interactive with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in producing morphological changes in the rat liver. Both compounds are known to produce a broad range of biochemical and morphological alterations including enzyme induction.

Groups (N=5) of female Sprague-Dawley rats were administered TCDD (0, 2.5, 25, 250, 1000 ng/kg bw/day) or PCB (0, 2, 20 μg/kg bw/day) alone, or in combination with each concentration of both compounds. Incorrect concentrations were published in a previous abstract. The test substance was mixed with corn oil and given by gavage at 2 ml/kg daily for 28 days. At the end of the experiment, the rats were killed and liver samples were prepared for transmission electron microscopy.

Type
Pathology
Copyright
Copyright © Microscopy Society of America 1997

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References

1Kimbrough, R.D., Crit. Rev. Toxicol. 133(1995)133.10.3109/10408449509021611CrossRefGoogle Scholar
2Ahlborg, U.G.et al., Chemosphere 28(1994)1049.10.1016/0045-6535(94)90324-7CrossRefGoogle Scholar
3H. Safe, , Crit. Rev. Toxicol. 24(1994)87.10.3109/10408449409049308CrossRefGoogle Scholar
4Connell, B.J.et al. USGEB Abst. March, 1997.Google Scholar
5Singh, A.et al., Ultrastruct. Pathol. 20(1996)275.10.3109/01913129609016325CrossRefGoogle Scholar