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Female Prostate Development: Morphological Analysis of the Budding Dynamic

Published online by Cambridge University Press:  18 January 2022

Fernanda C. A. dos Santos Open the ORCID record for Fernanda C. A. dos Santos [Opens in a new window] ,
Ana F. P. Negre ,
Daniel A. O. Rodríguez ,
Géssica C. de Sousa ,
Giovanna A. Rodrigues ,
Bruno D. A. Sanches ,
Hernandes F. Carvalho Open the ORCID record for Hernandes F. Carvalho [Opens in a new window] ,
Sebastião R. Taboga  and
Manoel F. Biancardi Open the ORCID record for Manoel F. Biancardi [Opens in a new window]
Fernanda C. A. dos Santos
Affiliation:
Department of Histology, Embryology, and Cell Biology, Federal University of Goiás, Campus Samambaia, Goiânia, Goiás 74690-900, Brazil
Ana F. P. Negre
Affiliation:
Department of Histology, Embryology, and Cell Biology, Federal University of Goiás, Campus Samambaia, Goiânia, Goiás 74690-900, Brazil
Daniel A. O. Rodríguez
Affiliation:
Department of Structural and Functional Biology, State University of Campinas, Campinas, São Paulo 13083-862, Brazil
Géssica C. de Sousa
Affiliation:
Department of Histology, Embryology, and Cell Biology, Federal University of Goiás, Campus Samambaia, Goiânia, Goiás 74690-900, Brazil
Giovanna A. Rodrigues
Affiliation:
Department of Histology, Embryology, and Cell Biology, Federal University of Goiás, Campus Samambaia, Goiânia, Goiás 74690-900, Brazil
Bruno D. A. Sanches
Affiliation:
Department of Structural and Functional Biology, State University of Campinas, Campinas, São Paulo 13083-862, Brazil
Hernandes F. Carvalho
Affiliation:
Department of Structural and Functional Biology, State University of Campinas, Campinas, São Paulo 13083-862, Brazil
Sebastião R. Taboga
Affiliation:
Department of Biology, State University of São Paulo, São José do Rio Preto, São Paulo 15054-000, Brazil
Manoel F. Biancardi*
Affiliation:
Department of Histology, Embryology, and Cell Biology, Federal University of Goiás, Campus Samambaia, Goiânia, Goiás 74690-900, Brazil
*
*Corresponding author: Manoel F. Biancardi, E-mail: [email protected]
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Abstract

The presence of the prostate in female mammals has long been known. However, pieces of information related to its development are still lacking. The aim of this study was to explore the budding dynamic during the initial prostate development in female gerbils. Pregnant females were timed, the fetuses were euthanized, and the urogenital sinus was dissected out between the embryonic days 20 and 24 (E20–E24 groups). Newborn pups (1-day-old; P1 group) underwent the same procedures. The female prostate development was based on epithelial buds which arose far from the paraurethral mesenchyme (PAM). The epithelial buds reached the PAM at prenatal day 24, crossing a small gap in the smooth muscle layer between the periurethral mesenchyme (PEM) and the PAM. Steroid nuclear receptors such as the androgen receptor and estrogen receptor alpha were localized in the PEM through the urethral wall, although some epithelial labeling was also present in the urogenital sinus epithelium (UGE). P63-positive cells were found only in the UGE, becoming restricted to the basal compartment after the 23rd prenatal day. The results showed that the gerbil female prostate exhibits a distinct budding pattern as compared to the male prostate development.

Keywords

femalegerbilorganogenesisparaurethral mesenchymeperiurethral mesenchyme
Type
Biological Applications
Information
Microscopy and Microanalysis , Volume 28 , Issue 1 , February 2022 , pp. 272 - 280
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of the Microscopy Society of America

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