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Examination of Biologically Active Nanocomplexes by Nanoparticle Tracking Analysis

Published online by Cambridge University Press:  09 May 2013

Nikolai Nikitin ,
Ekaterina Trifonova ,
Olga Karpova  and
Joseph Atabekov
Nikolai Nikitin*
Affiliation:
Department of Virology, Moscow State University, Moscow 119991, Russia
Ekaterina Trifonova
Affiliation:
Department of Virology, Moscow State University, Moscow 119991, Russia
Olga Karpova
Affiliation:
Department of Virology, Moscow State University, Moscow 119991, Russia Scientific and Potato Seed Producing Centrum, 2 Sovetskaya St., Moscow 143350, Russia
Joseph Atabekov
Affiliation:
Department of Virology, Moscow State University, Moscow 119991, Russia Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119991, Russia Scientific and Potato Seed Producing Centrum, 2 Sovetskaya St., Moscow 143350, Russia
*
*Corresponding author. E-mail: [email protected]
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Abstract

Nanoparticle tracking analysis (NTA) was first applied to biologically active nanocomplexes to obtain concurrent information on their size, state of aggregation, concentration, and antigenic specificity in liquid. The subject of the NTA was an immunogenic complex (a candidate nanovaccine) comprised of spherical particles (SPs) generated by thermal remodeling of the tobacco mosaic virus and Rubella virus tetraepitopes exposed on the surface of SP.

Keywords

nanoparticle tracking analysistobacco mosaic virusspherical particlesbiologically active nanocomplexes
Type
Biological Applications
Information
Microscopy and Microanalysis , Volume 19 , Issue 4 , August 2013 , pp. 808 - 813
Copyright
Copyright © Microscopy Society of America 2013 

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References

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