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Cryo-EM structural analysis of the SARS-CoV-2 Nucleocapsid protein

Published online by Cambridge University Press:  30 July 2021

Michael Casasanta ,
G.M. Jonaid ,
Liam Kaylor ,
William Luqiu ,
Maria Solares ,
Mariah Schroen ,
William Dearnaley ,
Jarad Wilson ,
Madelin Dukes  and
Deborah Kelly
Michael Casasanta
Affiliation:
Pennsylvania State University, State College, Pennsylvania, United States
G.M. Jonaid
Affiliation:
Pennsylvania State University, University Park, Pennsylvania, United States
Liam Kaylor
Affiliation:
Pennsylvania State University, University Park, Pennsylvania, United States
William Luqiu
Affiliation:
Duke University, United States
Maria Solares
Affiliation:
Pennsylvania State University, University Park, Pennsylvania, United States
Mariah Schroen
Affiliation:
Pennsylvania State University, United States
William Dearnaley
Affiliation:
Pennsylvania State University, University park, Pennsylvania, United States
Jarad Wilson
Affiliation:
RayBiotech, United States
Madelin Dukes
Affiliation:
Protochips, United States
Deborah Kelly
Affiliation:
Pennsylvania State University, University Park, Pennsylvania, United States

Abstract

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Type
Michael Rossmann Memorial Symposium
Information
Microscopy and Microanalysis , Volume 27 , Supplement S1 , August 2021 , pp. 1378 - 1380
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Microscopy Society of America

References

Alden, N., Varano, , et al. (2019). Cryo-EM-On-a-Chip: Custom-Designed Substrates for the 3D Analysis of Macromolecules. Small 15,Google Scholar
Varano, Cameron, et al. (2019). Customizable Cryo-EM Chips Improve 3D Analysis of Macromolecules. Microscopy and microanalysis 25, 1310–1311.Google Scholar
Carroni, M. & Saibil, H. R. (2016). Cryo electron microscopy to determine the structure of macromolecular complexes. Methods 95, 78–85.Google ScholarPubMed
Diao, B., et al. (2021). Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis of SARS-CoV-2 infection. Clinical microbiology and infection: the official publication of the Euro. Soc. of Clin. Micro. and Infectious Diseases 27, 289.e1–289.e4.Google Scholar
Kang, Y., et al. (2018). Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature 558, 553–558.Google Scholar
Li, T., et al. (2020). Serum SARS-COV-2 Nucleocapsid Protein: A Sensitivity and Specificity Early Diagnostic Marker for SARS-COV-2 Infection. Front. in cellular and infection micro. 10, 470.Google ScholarPubMed
McBride, R., van Zyl, M. & Fielding, B. C. (2014). The coronavirus nucleocapsid is a multifunctional protein. Viruses 6, 2991–3018.Google ScholarPubMed
Peng, L., Oganesyan, V., Wu, H., Dall'Acqua, W. F. & Damschroder, M. M. (2015). Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-α receptor 1 antibody. mAbs 7, 428–439.CrossRefGoogle ScholarPubMed
Woo, P. et al. (2004). Longitudinal profile of immunoglobulin G (IgG), IgM, and IgA antibodies against the severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in patients with pneumonia due to the SARS coronavirus. Clin. and diagnostic lab. immunology 11, 665–668.Google Scholar
Wrapp, D., et al. (2020). Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 367, 1260–1263.Google ScholarPubMed
Zeng, W., et al. (2020). Biochemical characterization of SARS-CoV-2 nucleocapsid protein. Biochem. and biophys. research comm. 527, 618–623.Google Scholar
Zhang, Y., et al. (2017). Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature 546, 248–253.CrossRefGoogle ScholarPubMed