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C-Ret Proto-Oncogene Expression in Human Prostate: An Immunohistochemical Evaluation

Published online by Cambridge University Press:  02 July 2020

D.M. Dawson ,
E. G. Lawrence ,
G. MacLennan  and
T.G. Pretlow
D.M. Dawson
Affiliation:
Institute of Pathology, Case Western Reserve University Medical Center, Cleveland, Ohio44106
E. G. Lawrence
Affiliation:
Institute of Pathology, Case Western Reserve University Medical Center, Cleveland, Ohio44106
G. MacLennan
Affiliation:
Institute of Pathology, Case Western Reserve University Medical Center, Cleveland, Ohio44106
T.G. Pretlow
Affiliation:
Institute of Pathology, Case Western Reserve University Medical Center, Cleveland, Ohio44106
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Extract

C-ret proto-oncogene encodes a protein in the tyrosine kinase (TK) family of transmembrane receptors for growth factors. C-ret expression has been identified in normal tissues and tumors of neural crest origin such as inherited MEN (multiple endocrine neoplasia) syndromes, particularly medullary thyroid cancers where there are confirmed germ-line mutations. Gene rearrangement has been observed in papillary thyroid carcinomas (PTC) and has been shown to have cytoplasmic localization of the altered gene product. C-ret proto-oncogene product is also necessary for the normal development of the peripheral nervous system, enteric nervous system and the kidney. A recent profile of the TK receptors in prostate cancer (PCA) identified c-ret protein in prostate cancer tissue and xenograft derived from human PCA. This study is the first to report the immunohistochemical (IH) evaluation of c-ret in human prostatic tissue.

Thirty radical prostatectomy specimens for PCA were formalin-fixed, sectioned at 5mm and paraffin-embedded.

Type
Neoplasia: Abnormal Cell Growth Or Death/Apoptosis? Insights From Microscopy
Information
Microscopy and Microanalysis , Volume 3 , Issue S2: Proceedings: Microscopy & Microanalysis '97, Microscopy Society of America 55th Annual Meeting, Microbeam Analysis Society 31st Annual Meeting, Histochemical Society 48th Annual Meeting, Cleveland, Ohio, August 10-14, 1997 , August 1997 , pp. 21 - 22
Copyright
Copyright © Microscopy Society of America 1997

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References

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