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Continuous heterogeneity analysis of CryoEM images through Zernike polynomials and spherical harmonics

Published online by Cambridge University Press:  30 July 2021

David Herreros Calero ,
Roy Lederman ,
James Krieger ,
David Myška ,
David Strelak ,
Jiri Filipovic ,
Ivet Bahar ,
Jose Maria Carazo  and
Carlos Oscar Sorzano
David Herreros Calero
Affiliation:
CSIC, Madrid, Spain
Roy Lederman
Affiliation:
Yale University, United States
James Krieger
Affiliation:
Department of Computational and Systems Biology at the University of Pittsburgh, United States
David Myška
Affiliation:
Institute of Computer Science, Masaryk University, Jihomoravsky kraj, Czech Republic
David Strelak
Affiliation:
CSIC, United States
Jiri Filipovic
Affiliation:
Institute of Computer Science, Masaryk University, United States
Ivet Bahar
Affiliation:
University of Pittsburgh, United States
Jose Maria Carazo
Affiliation:
CSIC, United States
Carlos Oscar Sorzano
Affiliation:
CSIC, United States

Abstract

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Type
3D Structures: From Macromolecular Assemblies to Whole Cells (3DEM FIG)
Information
Microscopy and Microanalysis , Volume 27 , Supplement S1 , August 2021 , pp. 1680 - 1682
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Microscopy Society of America

References

Sorzano, C.O.S., Jiménez, A, Mota, J, Vilas, J.L., Maluenda, D., M. Martı́nez, E. Ramı́rez-Aportela, Majtner, T., Segura, J., Sánchez-Garcı́a, R., Rancel, Y., Del Caño, L., Conesa, P., Melero, R., Jonic, S., Vargas, J., Cazals, F., Freyberg, Z., Krieger, J., Bahar, I., Marabini, R., and Carazo, J.M.. Survey of the analysis of continuous conformational variability of biological macromolecules by electron microscopy. Acta Crystallogr., 75:19–32, jan 2019.Google Scholar
Frank, J., Ourmazd, A.. Continuous changes in structure mapped by manifold embedding of single-particle data in cryo-EM. Methods, 100:61-67, may 2016.Google Scholar
Chen, M., Baker, M.L. and Ludtke, S.J.. Application of Deep Learning to CryoEM Heterogeneity Analysis. Biophy. Journal, 110:158a, feb 2016.Google Scholar