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Biological Evaluation of a Series of Amine-Containing Mixed-Ligand Copper(II) Coordination Compounds with 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide

Published online by Cambridge University Press:  20 May 2022

Aurelian Gulea ,
Ion Toderas ,
Olga Garbuz Open the ORCID record for Olga Garbuz [Opens in a new window] ,
Ianina Ulchina Open the ORCID record for Ianina Ulchina [Opens in a new window] ,
Vasilii Graur Open the ORCID record for Vasilii Graur [Opens in a new window]  and
Nadejda Railean
Aurelian Gulea
Affiliation:
Laboratory of Advanced Materials in Biopharmaceutics and Technics, Moldova State University, 60 Mateevici Street, MD 2009 Chisinau, Republic of Moldova
Ion Toderas
Affiliation:
Academy of Sciences of Moldova, Institute of Zoology, 1 Academiei Street, MD-2028 Chisinau, Republic of Moldova
Olga Garbuz*
Affiliation:
Laboratory of Advanced Materials in Biopharmaceutics and Technics, Moldova State University, 60 Mateevici Street, MD 2009 Chisinau, Republic of Moldova Academy of Sciences of Moldova, Institute of Zoology, 1 Academiei Street, MD-2028 Chisinau, Republic of Moldova
Ianina Ulchina
Affiliation:
Laboratory of Advanced Materials in Biopharmaceutics and Technics, Moldova State University, 60 Mateevici Street, MD 2009 Chisinau, Republic of Moldova
Vasilii Graur
Affiliation:
Laboratory of Advanced Materials in Biopharmaceutics and Technics, Moldova State University, 60 Mateevici Street, MD 2009 Chisinau, Republic of Moldova
Nadejda Railean
Affiliation:
Academy of Sciences of Moldova, Institute of Zoology, 1 Academiei Street, MD-2028 Chisinau, Republic of Moldova
*
*Corresponding author: Olga Garbuz, E-mail: [email protected]
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Abstract

Five compounds 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide (H2L), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]hydrazinylidene}methyl)phenolato-S,N,O:O]diaquadicopper(II) nitrate (1), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]hydrazinylidene}methyl)phenolato-S,N,O:O]diimidazoldicopper(II) nitrate (2), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis-(3,5-dibromopyridine)dicopper(II) nitrate (3), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis(4-methylpyridine)dicopper(II) nitrate hexahydrate (4) were synthesized. The antiproliferative properties of these compounds toward cancer cell lines RD, HeLa, and normal cell line MDCK have been investigated. The tested complexes surpass Doxorubicin (DOXO) in the efficiency of anticancer activity as their IC50 values toward cancer cells are lower than the corresponding values of DOXO and the selectivity indexes exceed the corresponding SI value of DOXO. The tested compounds demonstrated a high antioxidant effect against ABTS•+ radical cations as well as low toxicity on Daphnia magna.

Keywords

anticancer compoundantioxidant activityantiproliferative activityselective activitytoxicity
Type
Biological Applications
Information
Microscopy and Microanalysis , Volume 28 , Issue 5 , October 2022 , pp. 1696 - 1702
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of the Microscopy Society of America

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