Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2025-01-03T16:17:08.035Z Has data issue: false hasContentIssue false
  • English
  • Français

Angiogenesis in Neoplasia; Insights from in Situ Hybridization Studies

Published online by Cambridge University Press:  02 July 2020

LF. Brown  and
H.F. Dvorak
LF. Brown
Affiliation:
Departments of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215
H.F. Dvorak
Affiliation:
Departments of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215
Get access

Extract

The formation of vascular stroma (angiogenesis) is essential for tumor growth and may also influence invasion and metastasis. Quantitation of angiogenesis may serve as a prognostic marker in certain malignancies and novel therapies targeted at inhibiting angiogenesis may prove to play an important role in control of tumor growth.

In situ hybridization (ISH) studies have helped to define some of the molecular and cellular events responsible for the formation of vascular stroma in malignancy.

Vascular permeability factor (VPF), also known as vascular endothelial growth factor (VEGF), is a multifunctional cytokine associated with tumor angiogenesis. Vascular endothelial cells express at least two tyrosine kinase receptors for VPF, flt-1 and KDR. VPF acts as an angiogenic factor in several ways. It is an endothelial cell growth factor, alters endothelial cell gene expression, induces endothelial cell migration, and it is also a potent inducer of microvascular hyperpermeability (50,000 times as strong as histamine).

Type
Neoplasia: Abnormal Cell Growth Or Death/Apoptosis? Insights From Microscopy
Information
Microscopy and Microanalysis , Volume 3 , Issue S2: Proceedings: Microscopy & Microanalysis '97, Microscopy Society of America 55th Annual Meeting, Microbeam Analysis Society 31st Annual Meeting, Histochemical Society 48th Annual Meeting, Cleveland, Ohio, August 10-14, 1997 , August 1997 , pp. 35 - 36
Copyright
Copyright © Microscopy Society of America 1997

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)