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An expedited genes-to-drug approach using cryo-EM enabled structure based drug design

Published online by Cambridge University Press:  30 July 2021

Kenneth Borrelli ,
Leah Frye  and
Mazdak Radjaina
Kenneth Borrelli
Affiliation:
Schrodinger, New York, New York, United States
Leah Frye
Affiliation:
Schrodinger, United States
Mazdak Radjaina
Affiliation:
ThermoFisher, United States

Abstract

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Type
Cryo-EM in Drug Discovery
Information
Microscopy and Microanalysis , Volume 27 , Supplement S1 , August 2021 , pp. 3242 - 3244
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Microscopy Society of America

References

GemSpot: A Pipeline for Robust Modeling of Ligands into CryoEM MapsGoogle Scholar
Robertson, Michael J., van Zundert, Gydo C. P., Borrelli, Kenneth, Georgios Skiniotis bioRxiv 750778; doi: https://doi.org/10.1101/750778CrossRefGoogle Scholar
Li, Qi, Pellegrino, Jenna, Lee, D. John, Tran, Arthur, Wang, Ruoxi, Park, Jesslyn, et al. (2019): Synthesis and Mechanism of Action of Group a Streptogramin Antibiotics That Overcome Resistance. ChemRxiv. Preprint. https://doi.org/vol.26434/chemrxiv.8346107.v2CrossRefGoogle Scholar
Wei, J, Leit, S, Kuai, J, Therrien, E, Rafi, S, Harwood, HJ Jr, DeLaBarre, B, Tong, L. An allosteric mechanism for potent inhibition of human ATP-citrate lyase. Nature. 2019 Apr;568(7753):566-570.CrossRefGoogle ScholarPubMed