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Production and Analysis of High Resolution Polymer Replicas of Fibrillar Collagen

Published online by Cambridge University Press:  02 July 2020

P. Sims
Affiliation:
Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI53706
B. Todd
Affiliation:
Biomedical Engineering, Case Western Reserve University, Cleveland, OH44106
S. Eppell
Affiliation:
Biomedical Engineering, Case Western Reserve University, Cleveland, OH44106
T. Li
Affiliation:
School of Pharmacy, Purdue University, West Lafayette, IN47906
K. Park
Affiliation:
School of Pharmacy, Purdue University, West Lafayette, IN47906
R. Albrecht
Affiliation:
Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI53706
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Extract

Adherent cells generally construct the immediate substrate upon which they reside. This may occur via synthesis and secretion of new materials and/or by rearrangement and modification of existing substrate. The response of adherent cell types to an existing substrate can be influenced by a number of factors which include both the chemical and physical nature of the substrate. Cell adhesion, proliferation, differentiation and death can all be substrate dependent. Much effort has been directed toward chemical modification of substrates to regulate one or more of the parameters noted above. A significant, but somewhat smaller, degree of attention has been paid to the effects of the topography and microtopography on the cell response to substrate materials. Studies to date strongly suggest the topography is a significant factor in cell-substrate interactions. As noted above, it is most probable that both the chemistry and the structure of a substrate simultaneously influence the cellular response. However we wished to determine, particularly for artificial substrates, the role which microtopography can play in cell-substrate interactions.

Type
Biomaterials
Copyright
Copyright © Microscopy Society of America

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References

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