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Phase-Separated Morphologies in Poly(Psuedo Amino Acid)-PEG Blends and Copolymers for Tissue-Scaffolding Applications

Published online by Cambridge University Press:  02 July 2020

P. Prayoonthong ,
J. Taylor ,
M. Libera ,
M. Jaffe  and
J. Kohn
P. Prayoonthong
Affiliation:
Dept. of Chem., Biochem., and Matls. Engr., Stevens Inst, of Tech., Hoboken, NJ , 07030
J. Taylor
Affiliation:
Dept. of Chem., Biochem., and Matls. Engr., Stevens Inst, of Tech., Hoboken, NJ , 07030
M. Libera
Affiliation:
Dept. of Chem., Biochem., and Matls. Engr., Stevens Inst, of Tech., Hoboken, NJ , 07030
M. Jaffe
Affiliation:
Medical Device Concept Laboratory, 111 Lock Street, Newark, NJ, 07103
J. Kohn
Affiliation:
New Jersey Center for Biomaterials, Rutgers University, Piscataway, NJ08854
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Extract

Central to the successful advance of tissue engineering (e.g. 1, 2) is the development of highly engineered materials which trigger particular body responses to regenerate specific tissue or sets of tissue. Such properties as hydrophilicity, hydrolytic susceptibility, and protein-recognition behavior are critical to the success of tissue scaffolds. Poly(ethylene glycol) [PEG] is often introduced into scaffold polymers to tune hydrolytically controlled properties. Relatively little is known about the local morphology and nature of phase separation in these systems, however. This research studies the development of phase-separated morphology in blends and randommultiblock copolymers of a tyrosine-based poly(psuedo amino acid) [poly(DTE carbonate)] and PEG 1000 (fig. 1). This system exhibits attractive biocompatability, strength and modulus, and resorption behavior which can be controlled by main-chain and pendant-chain chemistries (3, 4).

The nature of phase separation was studied by bright-field TEM (Philips CM30 ST; CM20 FEG TEM/STEM) using solvent-cast thin films.

Type
Biomaterials
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 990 - 991
Copyright
Copyright © Microscopy Society of America

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References

References:

1.R, LanzaLanger, R., Chick, W. (1997), Principles of Tissue Engineering, Landes Bioscience, Georgetown Texas.Google Scholar
2.Pachence, J and Kohn, J. (1997), “Biodegradable Polymers for Tissue Engineering,” in ref. (1), 273.Google Scholar
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6. This research is partially supported by the NJ Commssion and Science and TechnologyGoogle Scholar