Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-09T06:13:24.269Z Has data issue: false hasContentIssue false

Molecular Mechanisms of Tumor Cell Survival, Growth, and Apoptosis During Organ-Specific Metastasis

Published online by Cambridge University Press:  02 July 2020

R. Radinsky
Affiliation:
Department of Cell Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 173, Houston, TX, 77030
C. D. Bucana
Affiliation:
Department of Cell Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 173, Houston, TX, 77030
C. H. Cho
Affiliation:
Department of Cell Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 173, Houston, TX, 77030
Get access

Extract

Metastasis is a highly selective nonrandom process favoring the survival of minor subpopulations of metatastatic cells that preexist within the primary tumor. The cellular and molecular mechanisms that regulate the metastasis of tumor cells to specific organs are diverse and both tumor and organ-specific (1). Many examples exist in which malignant tumors metastasize to specific organs. As Paget proposed in 1889 (2), and as our recent biological and molecular evidence demonstrates, the organ microenvironment influences the invasion, survival, growth, and apoptosis of particular tumor cells. This hypothesis explains metastatic colonization patterns that cannot be due to solely mechanical lodgement/anatomical considerations (1). Successful metastasis therefore involves the interaction of tumor cells with a compatible milieu provided by a particular organ environment.

Recent experimental evidence suggests that paracrine stimulation of tumor cells by organ-derived growth factors and cytokines is one mechanism which determines the target organ preference of disseminated cancer cells.

Type
Neoplasia: Abnormal Cell Growth Or Death/Apoptosis? Insights From Microscopy
Copyright
Copyright © Microscopy Society of America 1997

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Radinsky, R., Cancer and Metastasis Reviews, 14(1995)323338.10.1007/BF00690601CrossRefGoogle Scholar
2.Paget, S., Lancet, 1(1889) 571573.10.1016/S0140-6736(00)49915-0CrossRefGoogle Scholar
3.Radinsky, R.et al., Oncogene, 9 (1994) 18771883.Google Scholar
4.Radinsky, R.et al., Clinical Cancer Research, 1 (1995) 1931.Google Scholar
5.Dinney, C.P.N.et al., Clinical Cancer Research, 3 (1997) 161168.Google Scholar