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Effects of Nitric Oxide on Monocrotaline Induced Right Ventricular Hypertrophy and Lung Mast Cell Hyperplasia in Rats

Published online by Cambridge University Press:  02 July 2020

Kuen-Shan Hung  and
William H. Duncan
Kuen-Shan Hung
Affiliation:
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS66160-7400
William H. Duncan
Affiliation:
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS66160-7400
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Extract

Monocrotaline (M) induces pulmonary hypertension (PH) characterized by increased pulmonary arterial pressure, thickened pulmonary arterial walls, and right ventricular hypertrophy (RVH). In addition, numerous mast cells (MC) have been localized in M treated rats and these cells may have a role in causing PH and other lung injury because of their content of serotonin, which is a vasoconstrictor. Nitric oxide (NO) is a vasodilator that has been used in treatments of human patients and experimental animals with PH. The purpose of this study is to determine if NO inhalation can prevent or reverse RVH or MC accumulation induced by M.

Adult male Sprague-Dawley rats were divided into 5 groups (C, M3, MN3, M5, MN5). Group C served as controls without treatments. Groups M3 and M5 received one single subcutaneous injection of M (80mg/kg BW) and were sacrificed at 3 weeks (M3) or 5 weeks (M5) after injection.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 4 , Issue S2: Proceedings: Microscopy & Microanalysis '98, Microscopy Society of America 56th Annual Meeting, Microbeam Analysis Society 32nd Annual Meeting, Atlanta, Georgia July 12-16, 1998 , July 1998 , pp. 1072 - 1073
Copyright
Copyright © Microscopy Society of America

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References

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