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Diabetes-Induced Alterations in the Extracellular Matrix and Their Impact on Myocardial Function

Published online by Cambridge University Press:  05 January 2012

Brittany Law ,
Vennece Fowlkes ,
Jack G. Goldsmith ,
Wayne Carver  and
Edie C. Goldsmith
Brittany Law
Affiliation:
Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, 6439 Garners Ferry Rd., Columbia, SC 29209, USA
Vennece Fowlkes
Affiliation:
Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, 6439 Garners Ferry Rd., Columbia, SC 29209, USA
Jack G. Goldsmith
Affiliation:
Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, 6439 Garners Ferry Rd., Columbia, SC 29209, USA
Wayne Carver
Affiliation:
Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, 6439 Garners Ferry Rd., Columbia, SC 29209, USA
Edie C. Goldsmith*
Affiliation:
Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, 6439 Garners Ferry Rd., Columbia, SC 29209, USA
*
Corresponding author. E-mail: [email protected]
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Abstract

Diabetes is an increasing public health problem that is expected to escalate in the future due to the growing incidence of obesity in the western world. While this disease is well known for its devastating effects on the kidneys and vascular system, diabetic individuals can develop cardiac dysfunction, termed diabetic cardiomyopathy, in the absence of other cardiovascular risk factors such as hypertension or atherosclerosis. While much effort has gone into understanding the effects of elevated glucose or altered insulin sensitivity on cellular components within the heart, significant changes in the cardiac extracellular matrix (ECM) have also been noted. In this review article we highlight what is currently known regarding the effects diabetes has on both the expression and chemical modification of proteins within the ECM and how the fibrotic response often observed as a consequence of this disease can contribute to reduced cardiac function.

Keywords

diabetesextracellular matrixheartadvanced glycation end products (AGE)fibrosismyofibroblast
Type
Review Article
Information
Microscopy and Microanalysis , Volume 18 , Issue 1 , February 2012 , pp. 22 - 34
Copyright
Copyright © Microscopy Society of America 2012

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Footnotes

1

These authors contributed equally to this work.

References

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