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Development of Ion Channel Analysor Employing Pores of Subunit C of ATP Synthase

Published online by Cambridge University Press:  02 July 2020

J. E. M. McGeoch
J. E. M. McGeoch*
Affiliation:
Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue., Cambridge, MA02138
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Extract

Many pathological states are related to aberrant functioning of ion channels. Cures for these conditions involve the design of chemicals that will interact with the ion channels or a channel regulator to return their function to the normal level. A notable example of a pathological state associated with ion channel malfunction is the abnormal conductance of inward rectifying potassium channels associated with irregular heart beat. The development of drugs targeting ion channels requires efficient screening of thousands of potential channel ligands. Classically the function of ion channels are assayed by patch clamping which is a fairly elaborate technique and not efficient from the point of screening thousands of ligands. Here is described the development of a compact sensor device where an ion channel is made to function in a lipid bilayer in 50nm holes in silicon or polymer hardware.

Type
Biomaterials
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 978 - 979
Copyright
Copyright © Microscopy Society of America

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References

References:

1.Sakmann, B and Neher, ESingle Channel Recording Plenum Pub Corp New York (1983).Google Scholar
2.McGeoch, J. E. M et al Medical & Biological Engineering & Computing 38,(2000) 113.CrossRefGoogle Scholar
3.McGeoch, J.E.M. and Guidotti, G.Brain Research 766 (1997) 188.CrossRefGoogle Scholar
4.McGeoch, J. E. M.Palmer, D. N.Molecular Genetics Metabolism 66 (1999) 387.CrossRefGoogle Scholar
5.Llinas, R. R.Science 242 (1988) 1654.CrossRefGoogle Scholar
6. This research was sponsored by the Office of Naval Research and the Defense Advanced Research Projects Agency, Information Technology Office, N000 14-97-1-0653.Google Scholar