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CRYO-Tem Measurements of Membrane Elasticity in Equilibrium Vesicle Systems: Two Distinct Mechanisms of Stability

Published online by Cambridge University Press:  02 July 2020

B. Coldren ,
H.T. Jung  and
J. Zasadzinski
B. Coldren
Affiliation:
Department of Chemical Engineering, University of California at Santa Barbara, Santa Barbara, CA93106
H.T. Jung
Affiliation:
Department of Chemical Engineering, University of California at Santa Barbara, Santa Barbara, CA93106
J. Zasadzinski
Affiliation:
Department of Chemical Engineering, University of California at Santa Barbara, Santa Barbara, CA93106
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Extract

Aqueous mixtures of oppositely charged surfactants spontaneously form equilibrium phases of unilamellar vesicles.1 The wide variety of surfactants that display this behavior allows control over vesicle charge, size, and polydispersity. This may be useful for new applications in drug delivery, nanomaterials synthesis, and as tests of theoretical concepts of membrane organization and interactions.

A subtle competition between the entropy of mixing and the elastic properties of surfactant and lipid bilayers determines their phase behavior and morphology. The curvature energy per unit area of bilayer, fc, is

where R1 and R2 are the principle radii of curvature, K is the curvature modulus, and is the saddle-splay modulus. The spontaneous curvature, l/ro, is nonzero only if there is asymmetry between the two sides of the bilayer.

Type
Biomedical Applications
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 848 - 849
Copyright
Copyright © Microscopy Society of America

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References

References:

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