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Analysis of Counterfeit Coated Tablets and Multi-Layer Packaging Materials Using Infrared Microspectroscopic Imaging

Published online by Cambridge University Press:  12 April 2016

Taryn L. Winner ,
Adam Lanzarotta  and
André J. Sommer
Taryn L. Winner*
Affiliation:
Molecular Microspectroscopy Laboratory, Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio, USA
Adam Lanzarotta
Affiliation:
United States Food and Drug Administration Forensic Chemistry Center, Cincinnati, Ohio, USA
André J. Sommer
Affiliation:
Molecular Microspectroscopy Laboratory, Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio, USA
*
*Corresponding author. [email protected]
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Abstract

An effective method for detecting and characterizing counterfeit finished dosage forms and packaging materials is described in this study. Using attenuated total internal reflection Fourier transform infrared spectroscopic imaging, suspect tablet coating and core formulations as well as multi-layered foil safety seals, bottle labels, and cigarette tear tapes were analyzed and compared directly with those of a stored authentic product. The approach was effective for obtaining molecular information from structures as small as 6 μm.

Keywords

ATRFTIRcounterfeitpackagingpharmaceuticals
Type
Biological Applications
Information
Microscopy and Microanalysis , Volume 22 , Issue 3 , June 2016 , pp. 649 - 655
Copyright
Copyright © Microscopy Society of America 2016

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