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Waves of Autocrine Signaling in Patterned Epithelia
Published online by Cambridge University Press: 27 July 2010
Abstract
A biophysical model describing long-range cell-to-cell communication by a diffusible signal mediated by autocrine loops in developing epithelia in the presence of a morphogenetic pre-pattern is introduced. Under a number of approximations, the model reduces to a particular kind of bistable reaction-diffusion equation with strong heterogeneity. In the case of the heterogeneity in the form of a long strip a detailed analysis of signal propagation is possible, using a variational approach. It is shown that under a number of assumptions which can be easily verified for particular sets of model parameters, the equation admits a unique (up to translations) variational traveling wave solution. A global bifurcation structure of these solutions is investigated in a number of particular cases. It is demonstrated that the considered setting may provide a robust developmental regulatory mechanism for delivering chemical signals across large distances in developing epithelia.
- Type
- Research Article
- Information
- Mathematical Modelling of Natural Phenomena , Volume 5 , Issue 5: Reaction-diffusion waves , 2010 , pp. 46 - 63
- Copyright
- © EDP Sciences, 2010