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A Controlled Comparison of Methaminodiazepoxide (Chlordiazepoxide, “Librium”) and Amylobarbitone in the Treatment of Anxiety in Neurotic Patients

Published online by Cambridge University Press:  08 February 2018

F. A. Jenner ,
R. J. Kerry  and
D. Parkin
F. A. Jenner
Affiliation:
Department of Psychiatry, The United Sheffield Hospitals and the University of Sheffield
R. J. Kerry
Affiliation:
Department of Psychiatry, The United Sheffield Hospitals and the University of Sheffield
D. Parkin
Affiliation:
Department of Psychiatry, The United Sheffield Hospitals and the University of Sheffield
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Extract

In another paper, Jenner, Kerry and Parkin (1961) confirmed the views of earlier workers, Harris (1960) and Voelkel (1960) and others that methaminodiazepoxide is an effective agent in relieving anxiety in neurotic patients. That study was a blind controlled comparison of methaminodiazepoxide against lactose, but gave no indication of its value as compared with other drugs. The present paper is a comparison of methaminodiazepoxide (Librium, Roche) and amylobarbitone. The latter drug was felt to be one of the best known and most reliable drugs used in psychiatry for the treatment of anxiety. Raymond, Lucas, Beesley, O'Connell and Fraser-Roberts (1957) compared it very favourably with benactyzine, chlorpromazine, meprobamate, sedaltine and lactose. In that trial amylobarbitone was the only drug significantly better than lactose.

Type
Original Articles
Information
Journal of Mental Science , Volume 107 , Issue 448 , May 1961 , pp. 583 - 589
Copyright
Copyright © Royal College of Psychiatrists, 1961 

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References

Goodman, L. S., and Gilman, A., The Pharmacological Basis of Therapeutics, 1955. 2nd edition. New York: Macmillan Company, p. 138.Google Scholar
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Hines, L. B., “Methaminodiazepoxide (Librium) a Psychotherapeutic Drug”, Current Therapeutic Research, 1960, 2, 227.Google Scholar
Jenner, F. A., Kerry, R. J., and Parkin, D., “A Controlled Trial of Methaminodiazepoxide (‘Librium’ Roche) in the Treatment of Anxiety in Neurotic Patients”, J. Merit. Sci., 1961, 107, 575.Google Scholar
Raymond, M. J., Lucas, C. J., Beesley, M. L., O'Connell, B. A., and Fraser Roberts, J. A., “A Trial of Five Tranquillizing Drugs in Psychoneurosis”, Brit. Med. J., 1957, 2, 63.CrossRefGoogle Scholar
Voelkel, A., “Erfahrungen mit Librium bei psychomotorischen Unruhe- und Angstzuständen”, Med. experiment., 1960, 2, 170.Google Scholar
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