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Clinical Studies of a New Barbiturate (Nealbarbitone)

Published online by Cambridge University Press:  08 February 2018

A. A. Robin ,
D. P. Cronin  and
L. Scotton
A. A. Robin
Affiliation:
From Runwell Hospital and Southend General Hospital, Essex
D. P. Cronin
Affiliation:
From Runwell Hospital and Southend General Hospital, Essex
L. Scotton
Affiliation:
From Runwell Hospital and Southend General Hospital, Essex
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Extract

Brandström (1957) in Sweden, has recently resolved certain problems in the synthesis of barbiturates with a neopentyl group as one of the ring substituents and the resulting compound 5-allyl-5-neopentyl-barbituric acid∗ has been subjected to experimental studies which show it to be less hypnotic and anaesthetic than amylobarbitone or pentobarbitone sodium and yet protective to rats subjected to a stress situation after the technique of Jacobsen and Sonné (1955). The drug is rapidly absorbed after oral administration, and has a duration of action between that of amylobarbitone and phenobarbitone.

Type
Original Articles
Information
Journal of Mental Science , Volume 107 , Issue 446 , January 1961 , pp. 83 - 89
Copyright
Copyright © Royal College of Psychiatrists, 1961 

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References

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