American Journal of Insanity (July).—Dr. John P. Gray gives a condensed account of his pathological and microscopical investigations of 52 cases of insanity. He states that the vessels, nerve cells, and neuroglia undergo changes before marked impairment of the nerve conducting element can be detected. Increase of interstitial matter, multiplication of connective fibres, and diminution of connective nuclei, are prominent features of change. In chronic cases the increase of neuroglia takes place more in the gray matter than in the white, and is more marked in the anterior regions of the brain. This increase may be in connection with the capillaries, or more generally it occurs in localised regions, and circumscribed in walls formed by condensed minute connective fibres.