Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-27T04:48:02.817Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of temperature on the formation of hydroxyapatite

Published online by Cambridge University Press:  31 January 2011

M.T. Fulmer  and
P.W. Brown
M.T. Fulmer
Affiliation:
Department of Materials Science, Pennsylvania State University, University Park, Pennsylvania 16802-4801
P.W. Brown
Affiliation:
Department of Materials Science, Pennsylvania State University, University Park, Pennsylvania 16802-4801
Get access

Abstract

The formation of hydroxyapatite by an acid-base reaction between solid calcium phosphates at temperatures from 5 to 60 °C was examined. The basic reactant used is Ca4(PO4)2O, while the acidic reactants include CaHPO4, CaHPO4 · H2O, and Ca(H2PO4)2 · H2O. Rates of heat evolution during reaction were determined by isothermal calorimetry. The variations in the proportions of reactants and hydroxyapatite and the formation of intermediate products were assessed by x-ray diffraction. Development of microstructure was observed. Generally, hydroxyapatite formation occurs by rapid initial reaction followed by a period during which reaction occurs slowly. Apparent activation energies calculated for the reaction when CaHPO4 is the acidic reactant show differing values depending on its surface area. When the acidic reactant is Ca(H2PO4)2 · H2O, intermediate products are formed. At low temperatures the intermediate is CaHPO4 · 2H2O, while at higher temperatures it is CaHPO4. Above 38 °C, the rate during the period of slow reaction decreases with increasing temperature. This appears to be related to the retrograde solubilities of the reactants, CaHPO4 · 2H2O and CaHPO4, and of HAp.

Type
Articles
Information
Journal of Materials Research , Volume 8 , Issue 7 , July 1993 , pp. 1687 - 1696
Copyright
Copyright © Materials Research Society 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1Brown, W. E. and Chow, L. C.Cements Research Progress-1986, edited by Brown, P. W. (American Ceramic Society, Westerville, OH, 1987), pp. 351–379.Google Scholar
2Fulmer, M. and Brown, P.W. in Materials Synthesis Utilizing Biological Processes, edited by Rieke, P. C.Calvert, P. D. and Alper, M. (Mater. Res. Soc. Symp. Proc. 174, Pittsburgh, PA, 1990), p. 39.Google Scholar
3Fulmer, M. and Brown, P.W.J. Am. Ceram. Soc. 74, 934–940 (1991).Google Scholar
4Brown, P. W.Hocker, N., and Hoyle, S., J. Am. Ceram. Soc. 74, 1855–1861 (1991).Google Scholar
5Fulmer, M.T.Martin, R.I. and Brown, P.W.J. Mater. Sci. Materials in Medicine (in press).Google Scholar
6Brown, P.W.J. Am. Ceram. Soc. 75, 17–22 (1992).CrossRefGoogle Scholar
7Taylor, H. F. W.Cement Chemistry (Academic Press, New York, 1990).Google Scholar
8Feng, S.S. and Rockett, T.J.J. Am. Ceram. Soc. 62, 619–620 (1979).CrossRefGoogle Scholar
9Gregory, T.M.Moreno, E.G.Petal, J.M. and Brown, W.E.J. Res. Natl. Bur. Stand. 78A, 667–674 (1974).CrossRefGoogle Scholar
10VanWazer, J., Phosphorous and Its Compounds, Vol. I: Chemistry (1958).Google Scholar
11McDowell, H., Gregory, T. M. and Brown, W. E.J. Res. Natl. Bur. Stand. 81A, 273–281 (1977).CrossRefGoogle Scholar
12Martin, R. and Brown, P. W. unpublishe d work.Google Scholar
13Tomazic, B.B.Tung, M.S.Gregory, T.M. and Brown, W.E.Scan. Micro. 3 (1), 119–127 (1989).Google Scholar
14Brown, W. E.Lehr, J. R.Smith, J. T. and Frazier, A. W.Nature 196, 1050–1055 (1962).CrossRefGoogle Scholar
15LeGeros, R.Z.Daculsi, G., Orly, J., Abergas, T., and Torres, W.Scan. Micro. 3 (1), 129–138 (1989).Google Scholar