Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-26T23:20:44.107Z Has data issue: false hasContentIssue false
  • English
  • Français

Langerhans' cell histiocytosis of the temporal bone: successful treatment of sensorineural hearing loss with low-dose radiotherapy

Published online by Cambridge University Press:  13 June 2008

J K Zlodre ,
A T M Rennie  and
J D Ramsden
J K Zlodre*
Affiliation:
Department of Otorhinolaryngology, John Radcliffe Hospital, Oxford, UK
A T M Rennie
Affiliation:
Department of Neuroradiology, John Radcliffe Hospital, Oxford, UK
J D Ramsden
Affiliation:
Department of Otorhinolaryngology, John Radcliffe Hospital, Oxford, UK
*
Address for correspondence: Dr J K Zlodre, Department of Otorhinolaryngology, John Radcliffe Hospital, Oxford OX3 9DU, UK. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To present the successful treatment of sensorineural hearing loss secondary to Langerhans' cell histiocytosis with low-dose radiotherapy, and also the disparity between radiological resolution of Langerhans' cell histiocytosis lesions and lack of sensorineural hearing loss improvement, accompanied by a review of the literature on otolaryngological manifestations and management of Langerhans' cell histiocytosis.

Case report:

Langerhans' cell histiocytosis is a multisystem disease which frequently causes osseous lesions in the temporal bones. Hearing loss is usually conductive but may be sensorineural with lesions of the petrous temporal bone. We present a case of sensorineural hearing loss secondary to Langerhans' cell histiocytosis affecting the labyrinth and internal auditory meatus, which resolved following radiotherapy. Contralateral sensorineural hearing loss in the same patient, previously treated with chemotherapy, did not resolve despite radiological resolution of the temporal bone lesions.

Conclusion:

We suggest that timely radiotherapy for treatment of sensorineural hearing loss secondary to Langerhans' cell histiocytosis is an appropriate treatment option.

Keywords

HistiocytosisLangerhans-CellRadiotherapyHearing Loss, SensorineuralTemporal Bone
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 6 , June 2009 , pp. 676 - 679
Copyright
Copyright © JLO (1984) Limited 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Langerhans, P. On the nerves of human skin [in German]. Virchows Arch Pathol Anat Physiol Klin Med 1868;44:325–37CrossRefGoogle Scholar
2 Lichtenstein, L. Histiocytosis, X. Integration of eosinophilic granuloma of bone, “Letter-Siwe disease” and “Schuller-Christian disease” as related manifestations of a single nosologic entity. AMA Arch Pathol 1953;56:84–102Google Scholar
3 Chu, T, D'Angio, GJ, Favara, B, Ladisch, S, Nesbit, M, Pritchard, J. The Writing Group of the Histiocyte Society. Histiocytic syndromes in children. Lancet 1987;i:208–9Google Scholar
4 Arico, M, Girschikofsky, M, Genereau, T, Klersy, C, McClain, K, Grois, N et al. Langerhans cell histiocytosis in adults. Report from the International Registry of the Histiocyte Society. Eur J Cancer 2003;39:2341–8CrossRefGoogle ScholarPubMed
5 Broadbent, V, Davies, EG, Heaf, D, Pincott, JR, Pritchard, J, Levinsky, RJ et al. Spontaneous remission of multi-system histiocytosis X. Lancet 1984;i:253–4CrossRefGoogle Scholar
6 Vassallo, R, Ryu, JH, Colby, TV, Hartman, T, Limper, AH. Pulmonary Langerhans'-cell histiocytosis. N Engl J Med 2000;342:1969–78CrossRefGoogle ScholarPubMed
7 Willman, CL, Busque, L, Griffith, BB, Favara, BE, McClain, KL, Duncan, MH et al. Langerhans'-cell histiocytosis (histiocytosis X) – a clonal proliferative disease. N Engl J Med 1994;331:154–60CrossRefGoogle ScholarPubMed
8 Howarth, DM, Gilchrist, GS, Mullan, BP, Wiseman, GA, Edmonson, JH, Schomberg, PJ. Langerhans cell histiocytosis: diagnosis, natural history, management, and outcome. Cancer 1999;85:2278–903.0.CO;2-U>CrossRefGoogle ScholarPubMed
9 Stockschlaeder, M, Sucker, C. Adult Langerhans cell histiocytosis. Eur J Haematol 2006;76:363–8CrossRefGoogle ScholarPubMed
10 Irving, RM, Broadbent, V, Jones, NS. Langerhans' cell histiocytosis in childhood: management of head and neck manifestations. Laryngoscope 1994;104:64–70CrossRefGoogle ScholarPubMed
11 Cunningham, MJ, Curtin, HD, Jaffe, R, Stool, SE. Otologic manifestations of Langerhans' cell histiocytosis. Arch Otolaryngol Head Neck Surg 1989;115:807–13CrossRefGoogle ScholarPubMed
12 McCaffrey, TV, McDonald, TJ. Histiocytosis X of the ear and temporal bone: review of 22 cases. Laryngoscope 1979;89:1735–42CrossRefGoogle ScholarPubMed
13 Mosnier, I, Rondini-Gilli, E, Crosara, PTB, Belmatoug, N, Gyna-Corse, F, Cazals-Hatem, D et al. Langerhans' cell histiocytosis of the labyrinth in adults. Otol Neurotol 2004;25:27–32CrossRefGoogle ScholarPubMed
14 Nanduri, VR, Pritchard, J, Chong, WK, Phelps, PD, Sirimanna, K, Bailey, CM. Labyrinthine involvement in Langerhans' cell histiocytosis. Int J Pediatr Otorhinolaryngol 1998;46:109–15CrossRefGoogle ScholarPubMed
15 Hore, I, Mitchell, RB, Radcliffe, G, Quiney, R, Walker, T. Langerhans' cell histiocytosis – a rare cause of sudden onset unilateral sensorineural hearing loss. J Laryngol Otol 1999;113:1098–100CrossRefGoogle ScholarPubMed
16 Bauer, PW, MacDonald, CB, Domanowski, GF, Fuleihan, NS. Pathologic quiz case 2: Langerhans cell histiocytosis (LCH) of the temporal bone. Arch Otolaryngol Head Neck Surg 1998;124:1395–7Google ScholarPubMed
17 Cunningham, MJ, Curtin, HD, Butkiewicz, BL. Histiocytosis X of the temporal bone: CT findings. J Comput Assist Tomogr 1988;12:70–4CrossRefGoogle ScholarPubMed
18 Bonafe, A, Joomye, H, Jaeger, P, Fraysse, B, Manelfe, C. Histiocytosis X of the petrous bone in the adult: MRI. Neuroradiology 1994;36:330–3CrossRefGoogle ScholarPubMed
19 Seegenschmiedt, HM, Micke, O, Olschewski, T, Bruns, F, Heyd, R, Schaefer, U et al. Radiotherapy is effective in symptomatic Langerhans cell histiocytosis (LCH): long-term results of a multicenter study in 63 patients. Int J Radiat Oncol Biol Phys 2003;57(suppl 2):S251CrossRefGoogle Scholar
20 Anonsen, CK, Donaldson, SS. Langerhans' cell histiocytosis of the head and neck. Laryngoscope 1987;97:537–42CrossRefGoogle ScholarPubMed