Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-25T19:12:38.025Z Has data issue: false hasContentIssue false
  • English
  • Français

Familial Ménière's disease: clinical and genetic aspects

Published online by Cambridge University Press:  11 July 2008

A W Morrison ,
M E S Bailey  and
G A J Morrison
A W Morrison
Affiliation:
Late Honorary Consultant, The Royal London Hospital, London, UK
M E S Bailey
Affiliation:
Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, London, UK
G A J Morrison*
Affiliation:
Department of Otolaryngology, Guy's and St Thomas' NHS Trust, London, UK
*
Address for Correspondence: Mr Gavin A J Morrison, Department of Otolaryngology, St Thomas' Hospital, London SE1 7EH, UK. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background and purpose:

Ménière's disease is not uncommon, with an incidence in Caucasians of about one in 2000. The incidence peaks in the fifth decade. Cases are usually isolated or sporadic, but in perhaps five per cent other family members are affected. We report here the clinical and genetic characteristics of a comprehensive set of familial Ménière's disease cases from the UK.

Methods:

Forty-six affected families were studied. All cases were diagnosed using the American Academy of Otolaryngology–Head and Neck Surgery committee on hearing and equilibrium 1995, or more stringent, criteria.

Outcomes and results:

Autosomal dominant inheritance with reduced penetrance was the most likely mode of inheritance overall. Apparent genetic anticipation was observed, but may also be a result of ascertainment bias given the collection strategy. There was also a slight tendency for cases to result from maternal transmission within the families in this set. The family pedigrees are presented, and the authors have also set up a website at which all the pedigrees may be viewed in greater detail.

Keywords

Ménière's DiseaseFamilialEpidemiologyGeneticsDominantAnticipation
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 1 , January 2009 , pp. 29 - 37
Copyright
Copyright © JLO (1984) Limited 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Supplementary material

Supplementary Figures are available online at http://www.jlo.co.uk.

References

1 Committee on Hearing and Equilibrium guidelines for diagnosis and evaluation of therapy in Ménière's disease. Otolaryngol Head Neck Surg 1995;113:181–5CrossRefGoogle Scholar
2 Morrison, AW, Johnson, KJ. Genetics (molecular biology) and Ménière's disease. Otolaryngol Clin North Am 2002;35:497–516CrossRefGoogle ScholarPubMed
3 Celestino, D, Ralli, G. Incidence of Ménière's disease in Italy. Am J Otol 1991;12:135–8Google ScholarPubMed
4 Cawthorne, T, Hewlett, AB. Ménière's disease. Proc Roy Soc Med 1954;47:663–70Google ScholarPubMed
5 Harrison, MS, Naftalin, L. Ménière's Disease: Mechanism and Management. Springfield, Illinois: CC Thomas, 1968Google Scholar
6 Watanabe, I. Incidence of Ménière's disease, including some other epidemiological data. In: Oostervld, WJ, ed. Ménière's Disease. A Comprehensive Appraisal. Chichester: Wiley, 1983;9–23Google Scholar
7 Frieberg, V, Stahle, J. The epidemiology of Ménière's disease. In: Harris, JP, ed. Ménière's Disease. The Hague: Kugler, 1999;17–28Google Scholar
8 Kotimäki, J, Sorri, M, Aantaa, E, Nuutinen, J. Prevalence of Meniere disease in Finland. Laryngoscope 1999;109:748–53CrossRefGoogle ScholarPubMed
9 Stahle, J, Stahle, C, Arenberg, IK. Incidence of Ménière's disease. Arch Otolaryngol 1978;104:99–102CrossRefGoogle ScholarPubMed
10 Caparosa, RJ. Medical treatment of Ménière's disease. Laryngoscope 1963;73:666–72CrossRefGoogle Scholar
11 Fick, IA. Decompression of the labyrinth. Arch Otolaryngol 1964;79:447–58Google Scholar
12 Ashcroft, MT, Cruickshank, EK, Hinchcliffe, R, Jones, WI, Miall, WE, Wallace, J. A neurological, ophthalmological and audiological survey of a suburban Jamaican community. West Ind Med J 1967;16:233–45Google Scholar
13 Gibson, WPR. The physical and functional examination of the ear. In: Ballantyne, J. and Groves, J. (eds). Scott Brown's Otolaryngology, 4th edn. London: Butterworths, 1979;2:1–48Google Scholar
14 Wiet, RJ. Patterns of ear disease in south-western American Indians. Arch Otolaryngol 1979;105:381–5CrossRefGoogle Scholar
15 Brown, MR. Ménière's syndrome. Arch Neurol Psychiatry 1941;46:561–5Google Scholar
16 Brown, MR. The factor of heredity in labyrinthine deafness and paroxysmal nystagmus (Ménière's syndrome). Ann Otol Rhinol Laryngol 1949;56:665–70CrossRefGoogle Scholar
17 Bernstein, JM. Occurrence of episodic vertigo and hearing loss in families. Ann Otol Rhinol Laryngol 1965;74:1011–21CrossRefGoogle ScholarPubMed
18 Hinchcliffe, R. Personal and family medical history in Ménière's disease. J Laryngol Otol 1967;81:661–8CrossRefGoogle ScholarPubMed
19 Morrison, AW. Ménière's disease. J R Soc Med 1981;74:183–9CrossRefGoogle ScholarPubMed
20 Mizukoshi, K, Ino, H, Ishikawa, K, Watanabe, Y, Yamazaki, H, Kato, I et al. Epidemiological survey of definite cases of Ménière's disease collected by the seventeen members of the Ménière's disease research committee of Japan in 1975–1976. Adv Otorhinolaryngol 1979;25:106–11Google ScholarPubMed
21 Martini, A. Hereditary Ménière's disease; report of two families. Am J Otolaryngol 1982;3:163–7CrossRefGoogle ScholarPubMed
22 Birgerson, L, Gustavson, K-H, Stahle, J. Familial Ménière's disease. A genetic investigation. Acta Otolaryngol Suppl Stockh 1984;412:71–3Google Scholar
23 Birgerson, L, Gustavson, K-H, Stahle, J. Familial Ménière's disease: a genetic investigation. Am J Otol 1987;8:323–6Google ScholarPubMed
24 Klockars, T, Kentala, E. Inheritance of Ménière's disease in the Finnish population. Arch Otolaryngol Head Neck Surg 2007;133;73–7CrossRefGoogle ScholarPubMed
25 Morrison, AW, Xenellis, J. Immunological aspects of Ménière's disease. In: Veldman, JE, ed. Immunology, Histopathology and Tumour Immunology. Amsterdam: Kugler, 1987;9–14Google Scholar
26 Frykholm, C, Larsen, HC, Dahl, N, Klar, J, Rask-Andersen, H, Friberg, U. Familial Ménière's disease in five generations. Otol Neurotol 2006;27:681–6CrossRefGoogle ScholarPubMed
27 Oliveira, CA, Messias, CI, Ferrari, I. Occurrence of familial Ménière's syndrome and migraine in Brasilia. All Otol Rhinol Laryngol 2002;111:229–36CrossRefGoogle ScholarPubMed
28 Morrison, AW, Mowbray, JF, Williamson, R, Sheeka, S, Sodha, N, Koskinen, N. On genetic and environmental factors in Ménière's disease. Am J Otol 1994;15:35–9Google ScholarPubMed
29 Morrison, AW. Anticipation in Ménière's disease. J Laryngol Otol 1995;109:499–502CrossRefGoogle ScholarPubMed
30 Morrison, AW. Diagnostic and laboratory evaluation of Ménière's disease. In: Harris, JP, ed. Ménière's Disease The Hague: Kugler, 1999;291–304Google Scholar
31 Committee on Hearing and Equilibrium. Ménière's disease: criteria for diagnosis and evaluation of therapy for reporting. Trans Amer Acad Ophth Otolaryngol 1972;76:1462–4Google Scholar
32 Committee on Hearing and Equilibrium. Ménière's disease: criteria for diagnosis and evaluation of therapy for reporting. AAO-HNS Bulletin 1985;5:6–7Google Scholar
33 Stahle, J, Friberg, U, Svedberg, A. Long-term progression of Ménière's disease. Acta Otolaryngol Suppl Stockh 1991;485:78–83CrossRefGoogle ScholarPubMed
34 Morrison, AW. Endolymphatic hydrops. In: Morrison, AW, ed. Management of Sensorineural Deafness. London: Butterworths, 1975;145–74Google Scholar
35 Morrison, GAJ, Morrison, AW. On benign paroxysmal positional vertigo. Natural history and causation. In: Charachon, R, Garcia-Ibenez, E, eds. Long-term Results and Indications in Otology and Otoneurosurgery. Amsterdam: Kugler & Ghedini: 1991;269–72Google Scholar
36 Birgerson, L, Gustavson, K-H, Stahle, J. Familial Ménière's disease. Acta Otolaryngol Suppl Stockh 1984;412:71–3Google Scholar
37 Oliveira, CA, Braga, AM. Ménière's syndrome inherited as an autosomal dominant trait. Ann Otol Rhinol Laryngol 1992;101:590–4CrossRefGoogle ScholarPubMed
38 Arweiler, DJ, Jahnke, K, Grosse-Wilde, H. Ménière's Disease as an autosomal dominant illness [in German]. Laryngorhinootologie 1995;74:512–15CrossRefGoogle Scholar
39 Fung, K, Xie, Y, Hall, SF, Lillicrap, DP, Taylor, SA. Genetic basis of familial Ménière's disease. J Otolaryngol 2002;31:1–4CrossRefGoogle ScholarPubMed
40 Lynch, M, Cameron, TL, Knight, M, Kwok, TY, Thomas, P, Forrest, SM et al. Structural and mutation analysis of antiquitin as a candidate gene for Ménière's disease. Am J Med Genet 2002;110;397–9CrossRefGoogle Scholar
Supplementary material: File

Morrison supplementary figures

Morrison supplementary figures

Download Morrison supplementary figures(File)
File 170 KB