Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-26T02:42:16.225Z Has data issue: false hasContentIssue false
  • English
  • Français

Bromocriptine-associated ototoxicity*

Published online by Cambridge University Press:  29 June 2007

Philippe L. Lanthier ,
Marsha Y. Morgan  and
John Ballantyne
Philippe L. Lanthier
Affiliation:
Research Fellow.
Marsha Y. Morgan*
Affiliation:
Honorary Senior Lecturer in Medicine; William Gibson Scholar of the Royal Society of Medicine.
John Ballantyne
Affiliation:
Consulting ENT Surgeon.
*
Academic Department of Medicine, Royal Free Hospital School of Medicine, Rowland Hill Street, Hampstead, London NW3 4PF.
Get access Rights & Permissions [Opens in a new window]

Abstract

Three patients treated with bromocriptine for chronic hepatic encephalopathy showed audiometric evidence of bilateral sensori-neural hearing-loss. Audiometrically, the hearing improved in all three patients when the bromocriptine dosage was reduced, thus suggesting that this drug may produce a reversible ototoxicity.

Type
Clinical records
Information
The Journal of Laryngology & Otology , Volume 98 , Issue 4 , April 1984 , pp. 399 - 404
Copyright
Copyright © JLO (1984) Limited 1984

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

*

From the Royal Free Hospital, London.

References

Archer, D. F., Lattanzi, D. R., Moore, E. E., Harger, J. H., and Herbert, D. L. (1982) Bromocriptine treatment of women with suspected pituitary prolactin-secreting microadenomas. American Journal of Obstetrics and Gynecology, 143: 620–625.Google Scholar
Arnold, W., Nadol, J. B. Jr., and Weidaner, H. (1981) Ultrastructural histopathology in a case of human ototoxicity due to loop diuretics. Acta Otolaryngologica (Stockholm), 91: 399–414.CrossRefGoogle Scholar
Calne, D. B., Plotkin, C., Williams, A. C., Nutt, J. G., Neophytides, A., and Teychenne, P. F. (1978) Long-term treatment of Parkinsonism with bromocriptine. Lancet, i: 735–738.CrossRefGoogle Scholar
Durning, P., and Sellwood, R. A. (1982) Bromocriptine in severe cyclical breast pain. British Journal of Surgery, 69: 248–249.Google Scholar
Editorial (1982) Prolactinomas: bromocriptine rules OK? Lancet, i: 430–431.Google Scholar
Hawkins, J. E. Jr., Beger, V., and Aran, J.-M. (1967) Antibiotic insults to Corti's organ. In Sensory Hearing Processes and Disorders, pp. 411–425. Ed. Graham, A. B.. Little, Brown and Company, Boston.Google Scholar
Johnsson, L.-G., and Hawkins, J. E. Jr. (1972) Strial atrophy in clinical and experimental deafness. Laryngoscope, 83: 1105–1125.CrossRefGoogle Scholar
Johnston, D. G., McGregor, A., Ross, W. M., Kendall-Taylor, P., and Hall, R. (1981) Bromocriptine therapy for ‘non-functioning’ pituitary tumours. American Journal of Medicine, 71: 1059–1061.Google Scholar
Morgan, M. Y., Jakobovits, A. W., James, I. M., and Sherlock, S. (1980) Successful use of bromocriptine in the treatment of chronic hepatic encephalopathy. Gastroenterology, 78: 663–670.CrossRefGoogle ScholarPubMed
Moses, A. C., Molitch, M. E., Sawin, C. T., Jackson, I. M. D., Biller, B. J., Furlanetto, R., and Reichlin, S. (1981) Bromocriptine therapy in acromegaly: use in patients resistant to conventional therapy and effect on serum levels of somatomedin C. Journal of Clinical Endocrinology and Metabolism, 53: 752–758.Google Scholar
Parkes, J. D. (1979) Bromocriptine in the treatment of Parkinsonism. Drugs, 17: 365–382.CrossRefGoogle ScholarPubMed
Quabbe, H. J. (1982) Treatment of acromegaly by trans-sphenoidal operation, 90-Yttrium implantation and bromocriptine: results in 230 patients. Clinical Endocrinology, 16: 107–119.Google Scholar
Quick, C. A., and Duvall, A. J. (1970) Early change in the cochlear duct from ethacrynic acid: an electro-microscopic evaluation. Laryngoscope, 80: 954–965.Google Scholar
Sachdev, Y., Gopal, K., and Garg, V. K. (1981) Bromocriptine therapy in acromegaly. A long-term review of 75 cases. Postgraduate Medical Journal, 57: 210–216.CrossRefGoogle Scholar
Teychenne, P. F., Bersrud, D., Racy, A., Elton, R. L., and Vern, B. (1982) Bromocriptine: low-dose therapy in Parkinsons disease. Neurology (NY), 32: 577–583.CrossRefGoogle Scholar