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The effects of treatment with transfer factor, parasitic antigen and precipitated immunoglobulin on the parasitological and histopathological responses in Haemonchus contortus infection in lambs under six months of age

Published online by Cambridge University Press:  18 November 2009

Grace MacKenzie ,
A. R. Hunter  and
J. G. Ross
Grace MacKenzie
Affiliation:
Ministry of Agriculture, Fisheries and Food Veterinary Laboratory, Eskgrove, Lasswade, Midlothian, Scotland
A. R. Hunter
Affiliation:
Ministry of Agriculture, Fisheries and Food Veterinary Laboratory, Eskgrove, Lasswade, Midlothian, Scotland
J. G. Ross
Affiliation:
Ministry of Agriculture, Fisheries and Food Veterinary Laboratory, Eskgrove, Lasswade, Midlothian, Scotland
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Abstract

In lambs under six months of age infected with 10,000 H. contortus third stage larvae two effects were observed as a result of the treatment regimes administered: 1. Reduced adult worm burdens, indicating protection, occurred in the animals treated with combined transfer factor, adult parasitic antigen and precipitated immunoglobulin whereas other treatment combinations produced no significant effects. 2. Defined patterns of histological changes in the abomasa were associated with each treatment and cumulative effects were recognized when combined treatments were given. The responses induced by transfer factor treatment suggest the development of a hypersensitivity reaction outwith the changes seen in primary H. contortus challenge.

Type
Research Papers
Information
Journal of Helminthology , Volume 56 , Issue 4 , December 1982 , pp. 305 - 313
Copyright
Copyright © Cambridge University Press 1982

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References

REFERENCES

Benitez-Usher, C., Armour, J., Duncan, J. L., Urquhart, G. M. & Gettinby, G. (1977) A study of some factors influencing the immunisation of sheep against Haemonchus contortus using attenuated larvae. Veterinary Parasitology, 3, 327–342.CrossRefGoogle Scholar
Behnke, J. M. & Parish, H. A. (1979) Expulsion of Nematospiroides dubius from the intestine of mice treated with immune serum. Parasite Immunology, 1, 13–26.CrossRefGoogle ScholarPubMed
Charleston, W. A. G. (1965) Pathogenesis of experimental haemonchosis in sheep, with special reference to the devlopment of resistance. Journal of Comparative Pathology, 75, 55–67.CrossRefGoogle Scholar
Dargie, J. D. & Allonby, E. W. (1975) Pathophysiology of single challenge infections of H. contortus in Merino sheep; studies on red cell kinetics and the self-cure phenomenon. International Journal for Parasitology, 5, 147–157.CrossRefGoogle Scholar
Dineen, J. K., Ogilvie, B. M. & Kelly, J. D. (1973) Expulsion of Nippostrongylus brasiliensis from the intestine of rats. Immunology, 24, 467–475.Google ScholarPubMed
Dineen, J. K., Wagland, B. M. & Ronai, P. M. (1968) The cellular transfer of immunity to Trichostrongylus colubriformis in an isogenic strain of guinea-pig. Immunology, 15, 335–341.Google Scholar
Hunter, A. R. & Mackenzie, G. (1982) The pathogenesis of a single challenge dose of Haemonchus contortus in lambs under six months of age. Journal of Helminthology, 56, 135–144.CrossRefGoogle ScholarPubMed
Jarrett, E. E. E., Urquhart, G. M. & Douthwaite, R. M. (1969) Immunological unresponsiveness to helminth parasites. II. Antibody response and hypersensitivity reaction associated with Nippostrongylns brasiliensis infection in young rats. Experimental Parasitology, 24, 270–278.CrossRefGoogle ScholarPubMed
Maddison, S. E., Hicklin, M. D. & Kagan, I. G. (1976) Schistosoma mansoni; reduction in clinical manifestations and on worm burdens conferred by scrum and transfer factor from immune or normal Rhesus monkeys. Experimental Parasitology, 39, 29–39.CrossRefGoogle ScholarPubMed
Manton, V. J. A., Peacock, R., Poynter, D., Silverman, P. H. & Terry, R. J. (1962) The influence of age on naturally acquired resistance to H. contortus in lambs. Research in Veterinary Science, 3, 308–314.CrossRefGoogle Scholar
Miller, H. R. P. & Jarrett, W. F. H. (1971) Immune reactions in mucous membranes. I. Intestinal mast cell response during helminth expulsion in the rat. Immunology, 20, 277–288.Google ScholarPubMed
Murray, M. (1972) Immunity to animal parasites. Academic Press, New York.Google Scholar
Neilson, J. T. M. (1975) Failure to vaccinate lambs against Haemonchus contorus with functional metabolic antigens identified by immunoelectrophoresis. International Journal for Parasitology, 5, 427–430.CrossRefGoogle Scholar
Roberts, F. H. S. & O'Sullivan, B. J. (1950) Methods for egg counts and larval cultures for strongyles infesting the gastro-intestinal tract of cattle. Australian Journal of Agricultural Research, 1, 99–102.CrossRefGoogle Scholar
Ross, J. G. (1963) Immunogenic activity of the larval stages of Haemonchus placei. Nature, 197, 1221–1222.CrossRefGoogle Scholar
Ross, J. G. (1970) Investigations of acquired immunity to Trichostrongylus axei infections in seven-month-old lambs. British Veterinary Journal, 126, 4648–651.CrossRefGoogle ScholarPubMed
Ross, J. G., Duncan, J. L. & Halliday, W. G. (1979) Investigations of Haemonchus contortus infections in sheep. Comparison of irradiated larvae and transfer factor treatment. Research in Veterinary Science, 27, 258–259.CrossRefGoogle ScholarPubMed
Ross, J. G. & Halliday, W. G. (1979) Investigations of transfer factor activity in the transfer of immunity to Trichostrongylus axei infections on sheep. Research in Veterinary Science, 26, 41–46.CrossRefGoogle ScholarPubMed
Ross, J. G. & Halliday, W. G. (1981) Passive transfer of immunity to Trichostrongyle species infections in sheep. Investigations of specificity and limitations of transfer factor activity with Trichostrongylus axei infections. Veterinary Research Communications, 4, 287–290.CrossRefGoogle ScholarPubMed
Rothwell, T. L. W. (1978) Vaccination against the nematode T. colubriformis. III. Some observations on factors influencing immunity to infection in vaccinated guinea pigs. International Journal for Parasitology, 8, 33–37.CrossRefGoogle Scholar
Scott, H. L., Silverman, P. H., Mansfield, M. E. & Levine, H. S. (1971) Haemonchus contortus infection in sheep; active and passive immunity in sheep given oral iron supplement. American Journal of Veterinary Research 32, 249–262.Google ScholarPubMed
Smith, W. D. & Angus, K. W. (1980) Haemonchus contortus; attempts to immunise lambs with irradiated larvae. Research in Veterinary Science, 29, 45–50.CrossRefGoogle ScholarPubMed
Stewart, D. F. (1953) Studies on resistance of sheep to infestation with Haemonchus contortus and Trichostrongylus spp. and on the immunological reactions of sheep exposed to infestation. V. The nature of the ‘self-cure’ phenomenon. Australian Journal of Agricultural Research, 4, 100–117.CrossRefGoogle Scholar
Urquhart, G. M., Jarrett, W. F. H., Jennings, F. W., McIntyre, W. I. M. & Mulligan, W. (1966) Immunity to Haemonchus contortus infection; relationship between age and successful vaccination with irradiated larvae. American Journal of Veterinary Research, 27, 1645–1648.Google ScholarPubMed
Wakelin, D. & Lloyd, M. (1976) Accelerated expulsion of adult Trichinella spiralis in mice given lymphoid cells and serum from infected donors. Parasitology, 72, 307–315.CrossRefGoogle ScholarPubMed
Wilson, G. I. & Samson, K. S. (1974) Immunity to Haemonchus sp. in lambs; the immunising effects of various methods of larval administration. Research in Veterinary Science, 17, 390–394.CrossRefGoogle ScholarPubMed