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Influence of breed and parasite challenge on the immune response to naturally acquired intestinal nematode infection in sheep

Published online by Cambridge University Press:  18 April 2022

A.C.A. Albuquerque Open the ORCID record for A.C.A. Albuquerque [Opens in a new window] ,
F.A. Almeida Open the ORCID record for F.A. Almeida [Opens in a new window] ,
C.C. Bassetto Open the ORCID record for C.C. Bassetto [Opens in a new window] ,
J.G.G. Lins Open the ORCID record for J.G.G. Lins [Opens in a new window]  and
A.F.T. Amarante Open the ORCID record for A.F.T. Amarante [Opens in a new window]
A.C.A. Albuquerque*
Affiliation:
School of Veterinary Medicine and Animal Science, UNESP – São Paulo State University, Rua Professor Doutor Walter Mauricio Correa s/n, CEP 18618-681, Botucatu, SP, Brazil Institute of Biosciences, UNESP – São Paulo State University, Rua Professor Dr Antônio Celso Wagner Zanin, 250, CEP 18618-689, Botucatu, SP, Brazil
F.A. Almeida
Affiliation:
Institute of Biosciences, UNESP – São Paulo State University, Rua Professor Dr Antônio Celso Wagner Zanin, 250, CEP 18618-689, Botucatu, SP, Brazil
C.C. Bassetto
Affiliation:
Institute of Biosciences, UNESP – São Paulo State University, Rua Professor Dr Antônio Celso Wagner Zanin, 250, CEP 18618-689, Botucatu, SP, Brazil
J.G.G. Lins
Affiliation:
School of Veterinary Medicine and Animal Science, UNESP – São Paulo State University, Rua Professor Doutor Walter Mauricio Correa s/n, CEP 18618-681, Botucatu, SP, Brazil Institute of Biosciences, UNESP – São Paulo State University, Rua Professor Dr Antônio Celso Wagner Zanin, 250, CEP 18618-689, Botucatu, SP, Brazil
A.F.T. Amarante
Affiliation:
Institute of Biosciences, UNESP – São Paulo State University, Rua Professor Dr Antônio Celso Wagner Zanin, 250, CEP 18618-689, Botucatu, SP, Brazil
*
Author for correspondence: A.C.A. Albuquerque, E-mail: [email protected]
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Abstract

Natural infection by intestinal nematodes was assessed in Santa Ines and Ile de France sheep breeds, over a five-month grazing period, with emphasis on the development of the immune response in lambs under two anthelmintic treatment regimens. Nineteen Santa Ines and 19 Ile de France male lambs were allocated into two treatment groups: animals under suppressive treatment with anthelmintics; and animals under targeted selective treatment (TST). The nematodes Trichostrongylus colubriformis and Strongyloides papillosus showed the highest infection intensity in the TST animals in both breeds. Parasite-specific immunoglobulin G levels were significantly higher and more rapidly induced in Santa Ines lambs. Additionally, these lambs had higher levels of parasite-specific immunoglobulin A in intestinal mucus. Animals under TST had higher means of mast cells and globule leukocytes in the intestinal mucosa due to longer and greater parasite challenge in comparison with the suppressive group. A breed effect (P < 0.05) was recorded for mast cells, with Santa Ines lambs presenting the highest counts. Although Santa Ines lambs had lower intestinal nematode counts than Ile de France lambs, they had shown a large variation in T. colubriformis burden, with most of them presenting a marked worm burden, despite showing an earlier and more intense immune response to intestinal nematode infection.

Keywords

Intestinal nematodesanthelmintic treatmentmast cellsIgA
Type
Research Paper
Information
Journal of Helminthology , Volume 96 , 2022 , e27
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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