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Risk of Hepatitis C After Immunoadsorption

Published online by Cambridge University Press:  02 January 2015

Rolf Kaiser
Affiliation:
Institute of Medical Microbiology and Immunology, University of Bonn, Bonn, Germany
Oliver Geulen
Affiliation:
Institute of Medical Microbiology and Immunology, University of Bonn, Bonn, Germany
Bertfried Matz
Affiliation:
Institute of Medical Microbiology and Immunology, University of Bonn, Bonn, Germany
Hans H. Brackmann
Affiliation:
Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany
Ulrich Spengler
Affiliation:
Department of Internal Medicine, University of Bonn, Bonn, Germany
Michael H. Kramer*
Affiliation:
Institute of Hygiene, University of Bonn, Bonn, Germany
Martin Exner
Affiliation:
Institute of Hygiene, University of Bonn, Bonn, Germany
Wilhelm Nettekoven
Affiliation:
Medical Policlinic, University of Bonn, Bonn, Germany
You-Dschun Ko
Affiliation:
Medical Policlinic, University of Bonn, Bonn, Germany
Heike Zeitler
Affiliation:
Medical Policlinic, University of Bonn, Bonn, Germany
Hans Vetter
Affiliation:
Medical Policlinic, University of Bonn, Bonn, Germany
*
Center for Infectious Disease Epidemiology, Robert Koch-Institute, Stresemannstr. 90, 10963 Berlin, Germany

Abstract

An episode of acute hepatitis in a patient with hemophilia during immunoadsorption therapy initially was misinterpreted as a reactivated hepatitis C virus (HCV) infection, but ultimately was shown to be an exogenous reinfection during cohort treatment with another HCV-positive patient. This incident illustrates that policies for the prevention of nosocomial transmission of blood-borne pathogens, especially in cohort treatment units, may need to be reassessed.

Type
Concise Communications
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2002

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References

1.Brackmann, HH, Oldenburg, J, Schwaab, R. Immune tolerance for the treatment of factor VIII inhibitor: twenty years ‘Bonn Protocol’. Vox Sang 1996;70(suppl 1):3035.Google ScholarPubMed
2.Knöbl, P, Derfler, K, Korninger, L, et al. Elimination of acquired factor VIII antibodies by extracorporal antibody-based immunoadsorption (Ig-Therasorb). Thromb Haemost 1995;74:10351038.Google Scholar
3.Weiner, AJ, Geysen, HM, Christopherson, C, et al. Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections. Proc Natl Acad Sci U S A 1992;89:34683472.Google Scholar
4.Stoesser, G, Baker, W, van den Broek, A, et al. The EMBL Nucleotide Sequence Database. Nucleic Acids Res 2001;29:1721.Google Scholar
5.Golder, M, Chan, CLH, O'Shea, S, Corbett, K, Chrystie, IL, French, G. Potential risk of cross-infection during peripheral-venous access by contamination of tourniquets. Lancet 2000;355:44.Google Scholar
6.Lai, ME, Mazzoleni, AP, Argiolu, F, et al. Hepatitis C virus in multiple episodes of acute hepatitis in polytransfused thalassaemic children. Lancet 1994;343:388390.CrossRefGoogle ScholarPubMed