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The genetics of hormone-induced cyclic AMP production and Phospholipid N-methylation in inbred strains of mice

Published online by Cambridge University Press:  14 April 2009

Jasna Markovac  and
Robert P. Erickson
Jasna Markovac
Affiliation:
Department of Human Genetics, Box 015, University of Michigan Medical School, 1137 E. Catherine Street, Ann Arbor, Michigan 48109–0010
Robert P. Erickson
Affiliation:
Department of Human Genetics, Box 015, University of Michigan Medical School, 1137 E. Catherine Street, Ann Arbor, Michigan 48109–0010
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Genetic variation in hormone-sensitive cyclic AMP production was investigated among inbred strains of mice. Significant strain differences were observed in β-adrenergic- and glucagon-stimulated adenylate cyclase activity. Comparable differences were also found in membrane methyl-transferase I activity in these strains. Our results of studies using F1 progeny of high and low strains suggest a dominance of high MT I activity over low MT I activity. Investigation of recombinant inbred lines between the high and low strains indicates that MT I activity is regulated by at least two major genes; H-2-congenic lines of several inbred strains were then used to identify an association between hormone-stimulated MT I activity and the mouse major histocompatibility complex.

Type
Research Article
Information
Genetics Research , Volume 45 , Issue 2 , April 1985 , pp. 167 - 177
Copyright
Copyright © Cambridge University Press 1985

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