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Antagonism between novobiocin and coumermycin A1 in Bacillus subtilis
Published online by Cambridge University Press: 14 April 2009
Summary
When combinations of inhibitors acting on the subunit B of DNA gyrase were tested in Bac. subtilis strains, the growth-inhibiting effect of novobiocin was specifically antagonized by subinhibitory concentrations of coumermycin A1. An antagonism in the opposite direction was not observed.
Two alternative models are proposed, where the supercoiling decrease caused by novobiocin is antagonized by coumermycin.
This phenomenon seems to be characteristic of the Bac. subtilis species.
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