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The renin angiotensin aldosterone system and pregnancy

Published online by Cambridge University Press:  10 October 2008

F Broughton Pipkin
F Broughton Pipkin*
Affiliation:
Department of Obstetrics and Gynaecology, University Hospital, Nottingham, UK
*
F Broughton Pipkin, Department of Obstetrics and Gynaecology, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK
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Extract

Given the phylogenic antiquity of the renin angiotensin system (RAS) and the high degree of renin gene sequence conservation between species, it is perhaps not surprising that the RAS should be central to cardiovascular homeostasis. Nor, given the common embryological origin of the kidneys and reproductive tracts, is it especially surprising that the system should be influenced by, and may itself influence, the state of pregnancy. In this review I shall attempt to give an outline of the workings of the system in normal and in hypertensive pregnancy. The RAS is now known to be involved in spheres far beyond the ‘simple’ control of sodium and water homeostasis, and hence of blood pressure. Its roles in reproduction and in fetal life in animals have been very recently reviewed; this review will therefore confine itself to human studies unless otherwise stated.

Type
Articles
Information
Fetal and Maternal Medicine Review , Volume 4 , Issue 2 , July 1992 , pp. 59 - 71
Copyright
Copyright © Cambridge University Press 1992

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